Fluorescent Nanorods and Nanospheres for Real‐Time In Vivo Probing of Nanoparticle Shape‐Dependent Tumor Penetration

Vikash P. Chauhan(Harvard University), Zoran Popović(Massachusetts Institute of Technology), Ou Chen(Massachusetts Institute of Technology), Jian Cui(Massachusetts Institute of Technology), Dai Fukumura(Harvard University), Moungi G. Bawendi(Harvard University), Rakesh K. Jain(Harvard University)
Angewandte Chemie International Edition
October 6, 2011
Cited by 463Open Access
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Abstract

Shape dependent: Fluorescent quantum-dot-based nanospheres and nanorods with identical hydrodynamic size and surface properties but different aspect ratios were developed for real-time in vivo tumor imaging. The nanorods exhibited superior transport and distribution into mammary tumors in vivo versus nanospheres of similar plasma half-life. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.


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