Role of Mobile DNA in the Evolution of Vancomycin-Resistant <i>Enterococcus faecalis</i>
Ian T. Paulsen(Johns Hopkins University), Linda Banerjei, Garry S. A. Myers, William Nelson, R. Seshadri, Timothy D. Read, Derrick E. Fouts, Jonathan A. Eisen(Johns Hopkins University), Steven R. Gill, John F. Heidelberg, Hervé Tettelin, Robert J. Dodson, Lowell Umayam, Lauren Brinkac, Mauren Beanan, S. Daugherty, Robert T. DeBoy, Scott Durkin, James F. Kolonay, Ramana Madupu, William Nelson, Jessica Vamathevan, Bao Tran, Julia Upton, Thomas Arn Hansen, Jyoti Shetty, Hoda Khouri, Terry Utterback, Diana Radune, Karen A. Ketchum, Brian Dougherty, Claire M. Fraser(George Washington University)
Cited by 937
Abstract
The complete genome sequence of Enterococcus faecalis V583, a vancomycin-resistant clinical isolate, revealed that more than a quarter of the genome consists of probable mobile or foreign DNA. One of the predicted mobile elements is a previously unknown vanB vancomycin-resistance conjugative transposon. Three plasmids were identified, including two pheromone-sensing conjugative plasmids, one encoding a previously undescribed pheromone inhibitor. The apparent propensity for the incorporation of mobile elements probably contributed to the rapid acquisition and dissemination of drug resistance in the enterococci.
Related Papers
No related papers found
Powered by citation graph analysis