Facile and General Synthesis of Photoactivatable Xanthene Dyes
Laura M. Wysocki(Howard Hughes Medical Institute), Jonathan B. Grimm(Howard Hughes Medical Institute), Ariana N. Tkachuk(Howard Hughes Medical Institute), Timothy A. Brown(Howard Hughes Medical Institute), Eric Betzig(Howard Hughes Medical Institute), Luke D. Lavis(Howard Hughes Medical Institute)
Cited by 137Open Access
Abstract
Despite the apparent simplicity of the xanthene fluorophores, the preparation of caged derivatives with free carboxy groups remains a synthetic challenge. A straightforward and flexible strategy for preparing rhodamine and fluorescein derivatives was developed using reduced, “leuco” intermediates.
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