Assessing the Sensitivity of Spontaneous Baroreflex Control of the Heart: Deeper Insight Into Complex Physiology
Gianfranco Parati(IRCCS Istituto Auxologico Italiano), Marco Di Rienzo(Don Carlo Gnocchi Foundation), Paolo Castiglioni(Don Carlo Gnocchi Foundation), Malika Bouhaddi(Centre Hospitalier Universitaire de Besançon), Catherine Cerutti(Association pour l'Utilisation du Rein Artificiel dans la région Lyonnaise), Andrei Cividjian(Centre National de la Recherche Scientifique), Jean-Luc Elghozi(Hôpital Necker-Enfants Malades), Jacques‐Olivier Fortrat(Centre National de la Recherche Scientifique), Arlette Girard(Hôpital Necker-Enfants Malades), Ben Janssen(Maastricht University), C. Julien(Centre National de la Recherche Scientifique), John M. Karemaker(Amsterdam UMC Location University of Amsterdam), Ferdinando Iellamo(University of Rome Tor Vergata), Dominique Laude(Inserm), Е. В. Лукошкова(Institute of Experimental Cardiology), Massimo Pagani(University of Milan), Pontus B. Persson, Luc Quintin(Centre National de la Recherche Scientifique), Jacques Regnard(Centre Hospitalier Universitaire de Besançon), Julianna Ruediger(Technische Universität Dresden), Philip J. Saul(Medical University of South Carolina), Marco Vettorello(IRCCS Istituto Auxologico Italiano), Karel H. Wesseling, Giuseppe Mancia(IRCCS Istituto Auxologico Italiano)
Cited by 40Open Access
Abstract
While several papers support the physiological and clinical relevance of indices quantifying the sensitivity of spontaneous baroreflex control of heart rate (BRS), 1 Lipman et al 2 claim that they are unable to properly explore baroreflex function because spontaneous BRS was found to be quantitatively different from BRS values provided by the vasoactive drug injection technique and is unrelated to common carotid artery distensibility. We believe that this conclusion is not supported by Lipman's data, for the following reasons.
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