A Common Genetic Variant Is Associated with Adult and Childhood Obesity
Alan Herbert(Boston University), Norman P. Gerry(Boston University), Matthew B. McQueen(Boston University), Iris M. Heid(Boston University), Arne Pfeufer(Boston University), Thomas Illig(Boston University), H.‐Erich Wichmann(Boston University), Thomas Meitinger(Boston University), David J. Hunter(Boston University), Frank B. Hu(Boston University), Graham A. Colditz(Boston University), Anke Hinney(Boston University), Johannes Hebebrand(Boston University), Kerstin Koberwitz(Boston University), Xiaofeng Zhu(Boston University), Richard Cooper(Boston University), Kristin G. Ardlie(Boston University), Helen N. Lyon(Boston University), Joel N. Hirschhorn(Boston University), Nan M. Laird(Boston University), Marc E. Lenburg(Boston University), Christoph Lange(Boston University), Michael F. Christman(Boston University)
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Abstract
Obesity is a heritable trait and a risk factor for many common diseases such as type 2 diabetes, heart disease, and hypertension. We used a dense whole-genome scan of DNA samples from the Framingham Heart Study participants to identify a common genetic variant near the INSIG2 gene associated with obesity. We have replicated the finding in four separate samples composed of individuals of Western European ancestry, African Americans, and children. The obesity-predisposing genotype is present in 10% of individuals. Our study suggests that common genetic polymorphisms are important determinants of obesity.
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