Cloning of the β Cell High-Affinity Sulfonylurea Receptor: a Regulator of Insulin Secretion

Lydia Aguilar‐Bryan(Baylor College of Medicine), Colin G. Nichols(Washington University in St. Louis), Sérgio Wechsler(Baylor College of Medicine), John P. Clement(Baylor College of Medicine), A E Boyd(Baylor College of Medicine), Gabriela González(Baylor College of Medicine), Haydée Herrera-Sosa(Baylor College of Medicine), Kimberly Nguy(Baylor College of Medicine), Joseph Bryan(Baylor College of Medicine), Daniel A. Nelson(Baylor College of Medicine)
Science
April 21, 1995
10.1126/science.7716547
Cited by 1,327

Abstract

Sulfonylureas are a class of drugs widely used to promote insulin secretion in the treatment of non-insulin-dependent diabetes mellitus. These drugs interact with the sulfonylurea receptor of pancreatic beta cells and inhibit the conductance of adenosine triphosphate (ATP)-dependent potassium (KATP) channels. Cloning of complementary DNAs for the high-affinity sulfonylurea receptor indicates that it is a member of the ATP-binding cassette or traffic ATPase superfamily with multiple membrane-spanning domains and two nucleotide binding folds. The results suggest that the sulfonylurea receptor may sense changes in ATP and ADP concentration, affect KATP channel activity, and thereby modulate insulin release.

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