Macrolide Resistance in<i>Treponema pallidum</i>in the United States and Ireland
Sheila A. Lukehart(University of Washington), Charmie Godornes(University of Washington), Barbara J. Molini(University of Washington), Patricia Sonnett(University of Washington), Susan Hopkins(St. James's Hospital), Fiona Mulcahy(St. James's Hospital), Joseph Engelman(San Francisco Department of Public Health), Samuel J. Mitchell(San Francisco Department of Public Health), Anne Rompalo(Johns Hopkins University), Christina M. Marra(University of Washington), Jeffrey D. Klausner(San Francisco Department of Public Health)
Cited by 386Open Access
Abstract
An HIV-infected patient in San Francisco with primary syphilis was treated with azithromycin, but the lesion did not resolve. The authors of this case report confirmed resistance to azithromycin and identified a mutation in the 23S rRNA genes of T. pallidum. The mutation was also found in samples collected in Baltimore, Seattle, and Dublin.
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