Treatment of Metastatic Melanoma with Autologous CD4+ T Cells against NY-ESO-1
Naomi Hunder(Fred Hutch Cancer Center), Herschel Wallen(Fred Hutch Cancer Center), Jianhong Cao(Fred Hutch Cancer Center), Deborah W. Hendricks(Fred Hutch Cancer Center), J. Zachary Reilly(Fred Hutch Cancer Center), Rebecca M. Rodmyre(Fred Hutch Cancer Center), Achim A. Jungbluth(Memorial Sloan Kettering Cancer Center), Sacha Gnjatic(Memorial Sloan Kettering Cancer Center), John A. Thompson(University of Washington), Cassian Yee(University of Washington)
Cited by 902Open Access
Abstract
We developed an in vitro method for isolating and expanding autologous CD4+ T-cell clones with specificity for the melanoma-associated antigen NY-ESO-1. We infused these cells into a patient with refractory metastatic melanoma who had not undergone any previous conditioning or cytokine treatment. We show that the transferred CD4+ T cells mediated a durable clinical remission and led to endogenous responses against melanoma antigens other than NY-ESO-1.
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