A Spontaneous Lower Motor Neuron Disease Apparently Caused by Indigenous Type-C RNA Virus in Wild Mice2
Murray B. Gardner(University of Southern California), Brian E. Henderson(University of Southern California), J. Earle Officer(University of Southern California), Robert W. Rongey(University of Southern California), John C. Parker, Cynthia N. Oliver, John D. Estes(National Institutes of Health), Robert J. Huebner(National Institutes of Health)
Cited by 197Open Access
Abstract
Abstract A high incidence of spontaneous lower-limb paralysis occurred in a population of wild mice (Mus musculus) which had a high incidence of naturally occurring lymphoma and elevated indigenous type-C virus activity. Experimental transmission evidence indicated that both the neurologic and lymphomatous disorders almost certainly were caused by the indigenous type-C virus. The virus appeared to have a direct neurotropic effect on anterior horn neurons in the lower spinal cord.
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