Highly Enantioselective Insertion of Carbenoids into NH Bonds Catalyzed by Copper(I) Complexes of Binol Derivatives
Zongrui Hou(Sichuan University), Jun Wang(Sichuan University), Peng He(Sichuan University), Jing Wang(Sichuan University), Bo Qin(Sichuan University), Xiaohua Liu(Sichuan University), Lili Lin(Sichuan University), Xiaoming Feng(Sichuan University)
Cited by 135
Abstract
Secondary amines do it too! Catalytic asymmetric insertion of α-diazoesters in the NH bond of differently substituted amines has been successfully achieved (see scheme; M.S.=molecular sieves). For a wide substrate scope, excellent enantioselectivities (up to 98 % ee) and high yields (up to 99 %) were obtained under mild reaction conditions.
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