Profiling Solute Carrier Transporters in the Human Blood–Brain Barrier
Ethan G. Geier(University of California, San Francisco), E C Chen(University of California, San Francisco), Amy Webb(The Ohio State University), A C Papp(The Ohio State University), Sook Wah Yee(University of California, San Francisco), Wolfgang Sadée(The Ohio State University), Kathleen M. Giacomini(University of California, San Francisco)
Cited by 133Open Access
Abstract
The neuroprotective function of the blood-brain barrier (BBB) presents a major challenge for drug delivery to the central nervous system (CNS). Critical to this function, BBB membrane transporters include the ATP-binding cassette (ABC) transporters, which limit drug penetration across the BBB, and the less-well-studied solute carrier (SLC) transporters. In this work, expression profiling of 359 SLC transporters, comparative expression analysis with kidney and liver, and immunoassays in brain microvessels (BMVs) identified previously unknown transporters at the human BBB.
Related Papers
Renal Transporters in Drug Development
Kari M. Morrissey, Sophie L. Stocker, Matthias Wittwer et al.|The Annual Review of Pharmacology and Toxicology|2012|317
Biotin-Responsive Basal Ganglia Disease Maps to 2q36.3 and Is Due to Mutations in SLC19A3
Wenqi Zeng, Eiman A. Al-Yamani, James S. Acierno et al.|The American Journal of Human Genetics|2005|215
Chondroitin sulfate: A key molecule in the brain matrix
Jessica C. F. Kwok, Philippa M. Warren, James W. Fawcett|The International Journal of Biochemistry & Cell Biology|2012|136