Deciding Whether To Go with the Flow: Evaluating the Merits of Flow Reactors for Synthesis
Ryan L. Hartman(University of Alabama), Jonathan P. McMullen(Merck & Co., Inc., Rahway, NJ, USA (United States)), Klavs F. Jensen(Massachusetts Institute of Technology)
Cited by 998
Abstract
The fine chemicals and pharmaceutical industries are transforming how their products are manufactured, where economically favorable, from traditional batchwise processes to continuous flow. This evolution is impacting synthetic chemistry on all scales-from the laboratory to full production. This Review discusses the relative merits of batch and micro flow reactors for performing synthetic chemistry in the laboratory.