Complete genome sequence and comparative genomic analysis of an emerging human pathogen, serotype V<i>Streptococcus agalactiae</i>

Hervé Tettelin(Brigham and Women's Hospital), Vega Masignani(Brigham and Women's Hospital), Michael J. Cieslewicz(Brigham and Women's Hospital), Jonathan A. Eisen(Brigham and Women's Hospital), Scott N. Peterson(Brigham and Women's Hospital), Michael R. Wessels(Brigham and Women's Hospital), Ian T. Paulsen(Brigham and Women's Hospital), Karen E. Nelson(Brigham and Women's Hospital), Immaculada Margarit(Brigham and Women's Hospital), Timothy D. Read(Brigham and Women's Hospital), Lawrence C. Madoff(Brigham and Women's Hospital), Alex M. Wolf(Brigham and Women's Hospital), Maureen J. Beanan(Brigham and Women's Hospital), Lauren Brinkac(Brigham and Women's Hospital), Sean C. Daugherty(Brigham and Women's Hospital), Robert T. DeBoy(Brigham and Women's Hospital), A. Scott Durkin(Brigham and Women's Hospital), James F. Kolonay(Brigham and Women's Hospital), Ramana Madupu(Brigham and Women's Hospital), Matthew R. Lewis(Brigham and Women's Hospital), Diana Radune(Brigham and Women's Hospital), Nadezhda B. Fedorova(Brigham and Women's Hospital), David J. Scanlan(Brigham and Women's Hospital), Hoda Khouri(Brigham and Women's Hospital), Stephanie Mulligan(Brigham and Women's Hospital), Heather A. Carty(Brigham and Women's Hospital), Robin T. Cline(Brigham and Women's Hospital), Susan E. Van Aken(Brigham and Women's Hospital), John Gill(Brigham and Women's Hospital), Maria Scarselli(Brigham and Women's Hospital), Marirosa Mora(Brigham and Women's Hospital), Emilia Tiziana Iacobini(Brigham and Women's Hospital), Cecilia Brettoni(Brigham and Women's Hospital), G. Galli(Brigham and Women's Hospital), Massimo A. Mariani(Brigham and Women's Hospital), Filippo Vegni(Brigham and Women's Hospital), Domenico Maione(Brigham and Women's Hospital), Daniela Rinaudo(Brigham and Women's Hospital), Rino Rappuoli(Brigham and Women's Hospital), John L. Telford(Brigham and Women's Hospital), Dennis L. Kasper(Brigham and Women's Hospital), Guido Grandi(Brigham and Women's Hospital), Claire M. Fraser(Brigham and Women's Hospital)
Proceedings of the National Academy of Sciences
August 28, 2002
10.1073/pnas.182380799
Cited by 491Open Access
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Abstract

The 2,160,267 bp genome sequence of Streptococcus agalactiae, the leading cause of bacterial sepsis, pneumonia, and meningitis in neonates in the U.S. and Europe, is predicted to encode 2,175 genes. Genome comparisons among S. agalactiae, Streptococcus pneumoniae, Streptococcus pyogenes, and the other completely sequenced genomes identified genes specific to the streptococci and to S. agalactiae. These in silico analyses, combined with comparative genome hybridization experiments between the sequenced serotype V strain 2603 V/R and 19 S. agalactiae strains from several serotypes using whole-genome microarrays, revealed the genetic heterogeneity among S. agalactiae strains, even of the same serotype, and provided insights into the evolution of virulence mechanisms.

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