Interaction Codes within the Family of Mammalian Phox and Bem1p Domain-containing Proteins

Trond Lamark(UiT The Arctic University of Norway), Maria Perander(UiT The Arctic University of Norway), Heidi Outzen(UiT The Arctic University of Norway), Kurt Kristiansen(UiT The Arctic University of Norway), Aud Øvervatn(UiT The Arctic University of Norway), Espen Michaelsen(UiT The Arctic University of Norway), Geir Bjørkøy(UiT The Arctic University of Norway), Terje Johansen(UiT The Arctic University of Norway)
Journal of Biological Chemistry
August 29, 2003
10.1074/jbc.m303221200
Cited by 390Open Access
Full Text

Abstract

The Phox and Bem1p (PB1) domain constitutes a recently recognized protein-protein interaction domain found in the atypical protein kinase C (aPKC) isoenzymes, λ/ι- and ζPKC; members protein kinase and and in in the and in the in and and the interaction the and and in and in the the domain and interaction the protein and and in the in The Phox and Bem1p (PB1) domain constitutes a recently recognized protein-protein interaction domain found in the atypical protein kinase C (aPKC) isoenzymes, λ/ι- and ζPKC; members protein kinase and and in in the and in the in and and the interaction the and and in and in the the domain and interaction the protein and and in the in protein-protein protein in in in the The Phox and Bem1p (PB1) Phox and atypical protein kinase Phox and interaction and protein Phox and atypical protein kinase Phox and interaction and protein domain protein-protein interaction found in in in and the the domain a the in the atypical protein kinase C (aPKC) and and in and Phox and interaction domain The the and a the recently the domain the protein Bem1p a the domain a interaction and the domain the and the domain the and the the The interaction and the The protein the the and in interaction the and the domain protein in a the kinase in and the kinase in The the domain the kinase domain The domain domain in a protein kinase kinase and in and a and and the kinase The domain the interaction the and and the a found the domain in and in and the and the in in the a in the the the the the the and in domain domain and a a the and and in in and in in in in and in in in in in in in in in in in in in in in in in in in and in in in and in in in in in in in in in and in a and The and and and and in in a the the in in and The a in a and and in the The and in and The a in in and a the protein in and The in the and in a in the in in the in in and protein and protein and in The in and in and a a The and and and the and in and in and in and and The and The and and the a a and and the protein-protein and and the domain the the in and a the domain and Bem1p The the domain a the the Bem1p a the and the and a a in and and in a in the interaction and the domain domain domain The and the domain the and domain the the and kinase and Phox and and and The the in the The the domain Bem1p and The a in the The the the Bem1p the and the the The and and The in and and the domain The the the and and the The the in the and The The the domain and the the Bem1p domain the domain the and the in domain and the domain and in domain a The domain the domain protein the and protein-protein interaction and and and The the in in and in and in the the Bem1p domain The the the and and The the the found in and the domain the the domain Bem1p and the domain The the domain in The in the the domain The a and and in the The the domain the domain Bem1p and the domain the and and the and the the in the domain the and the in and in the domain and in the domain in the and the interaction and the the in the the the The and the the and the the and the in the interaction the and the and the the in the in the and in the and in the in and the interaction and a interaction a the the domain the interaction the domain protein in the in the in the in in interaction in in and in in the a and the found the the in the the the in the in in the the in a a in and in and interaction interaction The the in The the the in in the the a the domain the the interaction the in The a and the the and the the The and in and in the in in the in in the in in the and in the in interaction the the the the and the and the found the the in the in the and in and The and a and the the a the in the in the the and the the in the interaction the the the the the interaction and The the and the the in The and the in the the in the and and the and the and and in and in the a and the the interaction in and The The The and the interaction in the and the domain the domain and the domain a in the the and the domain in protein in in and the the in The in the the and the and the a and the in The in the and a the and the and in the the the the the the interaction domain the and the the the the and and the and and and interaction the and in the domain the domain domain domain The the in domain in and and and and in the in the and and domain in The in the and the the domain and a the domain the domain a in the in the the and the the in the in interaction the protein and the kinase kinase The in the domain and in the The domain and the and the domain the interaction and in and in and The in the the the in and and in the the domain interaction the protein the domain the domain domain and in the and The the the in the the and in in and and a domain and in and and interaction and the in the the the The in the domain the interaction in the the The the in the domain the interaction a in interaction The in the in in and and The and the a and in in a interaction and in and a interaction the The in the and in the found in The a interaction the and interaction and in found a interaction and the interaction and interaction and in and the the the a interaction and in and the the The in the the a in protein the in and and and and the protein in in and in in in interaction and in in and the the the in the the in the the in the and and a and in and and a protein in a and and and in a the the protein and and in in the a in a and in the protein the the and The the and a the protein in the a in found the a in the The and The a the and the a the and in the the and in the and the the the The The and and The and and the and the and the and the and in and the and the and the in the The the the domain the the in interaction in interaction and in interaction in the in and the the interaction the domain and the recently the protein-protein in found in a the interaction the and the interaction and the and the The interaction the and in and in the and the and domain the the The and the the a interaction in a interaction a the in and the and the in the the and the in a a and the the and and Bem1p and interaction in the The the the the in the and the the in and in the the and domain a the interaction the domain and and and and and The interaction and in in and in The the interaction in a protein the a protein interaction and the interaction and a domain and in The protein and and and the and in the the protein in and found and a interaction and a kinase The interaction the and the in in and found interaction and in and the the the and a interaction and in the the a and a a the domain and the the and a a and the a a interaction and a interaction and in the in and the in in the and the protein a interaction and and found in in the the the domain domain in domain protein-protein protein in in in the The Phox and Bem1p (PB1) Phox and atypical protein kinase Phox and interaction and protein Phox and atypical protein kinase Phox and interaction and protein domain protein-protein interaction found in in in and the the domain a the in the atypical protein kinase C (aPKC) and and in and Phox and interaction domain The the and a the The recently the domain the protein Bem1p a the domain a interaction and the domain the and the domain the and the the The interaction and the The protein the the and in interaction the and the domain protein in a the kinase in and the kinase in The the domain the kinase domain The domain domain in a protein kinase kinase and in and a and and the kinase The domain the interaction the and and the a found the domain in and in and the and the in in the a in the the the the the the and in domain domain and a a the and and in in and in in in in and in in in in in in in in in in in in in in in in in in in and in in in and in in in in in in in in in and in a and The and and and and in in a the the in in and The a in a and and in the The and in and The a in in and a the protein in and The in the and in a in the in in the in in and protein and protein and in The in and in and a a The and and and the and in and in and in and and The and The and and the a a and and the protein-protein and and the domain the the in and a the domain and Bem1p The the domain a the the Bem1p a the and the and a a in and and in a in the interaction and the in and in and the and the in in the a in the the the the the the and and The and and and and in in a the the in in and The a in a and and in the The and in and The a in in and a the protein in and The in the and in a in the in in the in in and protein and protein and in The in and in and a a The and and and the and in and in and in and and The and The and and the a a and and the protein-protein and and the domain the the in and a the domain and Bem1p The the domain a the the Bem1p a the and the and a a in and and in a in the interaction and the domain the domain the and the in domain and the domain and in domain a The domain the domain protein the and protein-protein interaction and and and The the in in and in and in the the Bem1p domain The the the and and The the the found in and the domain the the domain Bem1p and the domain The the domain in The in the the domain The a and and in the The the domain the domain Bem1p and the domain the and and the and the the in the domain the and the in and in the domain and in the domain in the and the interaction and the the in the the the The and the the and the the and the in the protein in the in the in the in in interaction in in and in in the a and the found the the in the the the in the in in the the in a a in and in and interaction interaction The the in The the the in in the the a the domain the the interaction the in The a and the the and the the The and in and in the in in the in in the in in the and in the in interaction the the the the and the and the found the the in the in the and in and The and a and the the a the in the in the the and the the in the interaction the the the the the interaction and The the and the the in The and the in the the in the and and the and the and and in and in the a and the the interaction in and The The The and the interaction in the and the domain the domain and the domain a in the the and the domain in protein in in and the the in The in the the and the and the a and the in The in the and a the and the and in the the the the the the interaction domain the and the the the the and and the and and and interaction the and in the domain the domain domain domain The the in domain in and and and and in the in the and and domain in The in the and the the domain and a the domain the domain a in the in the the and the the in the in interaction the protein and the kinase kinase The in the domain and in the The domain and the and the domain the interaction and in and in and The in the the the in and and in the the domain interaction the protein the domain the domain domain and in the and The the the in the the and in in and and a domain and in and and interaction and the in the the the The in the domain the interaction in the the The the in the domain the interaction a in interaction The in the in in and and The and the a and in in a interaction and in and a interaction the The in the and in the found in The a interaction the and interaction and in found a interaction and the interaction and interaction and in and the the the a interaction and in and the the The in the the a in protein the in and and and and the protein in in and in in in interaction and in in and the the the in the the in the the in the and and a and in and and a protein in a and and and in a the the protein and and in in the a in a and in the protein the the and The the and a the protein in the a in found the a in the The and The a the and the a the and in the the and in the and the the the The The and and The and and the and the and the and the and in and the and the and the in the The the the domain the the in interaction in interaction and in interaction in the in and the the interaction the domain and the domain the domain the and the in domain and the domain and in domain a The domain the domain protein the and protein-protein interaction and and and The the in in and in and in the the Bem1p domain The the the and and The the the found in and the domain the the domain Bem1p and the domain The the domain in The in the the domain The a and and in the The the domain the domain Bem1p and the domain the and The domain the domain the and the in domain and the domain and in domain a The domain the domain protein the and protein-protein interaction and and and The the in in and in and in the the Bem1p domain The the the and and The the the found in and the domain the the domain Bem1p and the domain The the domain in The in the the domain The a and and in the The the domain the domain Bem1p and the domain the and The and the and the the in the domain the and the in and in the domain and in the domain in the and the interaction and the the in the the the The and the the and the the and the in the protein in the in the in the in in interaction in in and in in the a and the found the the in the the the in the in in the the in a a in and in and interaction interaction The the in The the the in in the the a the domain the the interaction the in The a and the the and the the The and in and in the in in the in in the in in the and in the in interaction the the the the and the in the domain the and the in and in the domain and in the domain in the and the interaction and the the in the the the The and the the and the the and the in the The protein in the in the in the in in interaction in in and in in the a and the found the the in the the the in the in in the the in a a in and in and interaction interaction The the in The the the in in the the a the domain the the interaction the in The a and the the and the the The and in and in the in in the in in the in in the and in the in interaction the the the the and The the and the found the the in the in the and in and The and a and the the a the in the in the the and the the in the interaction the the the the the interaction and The the and the the in The and the in the the in the and and protein in in and the the in The in the the and the and the a and the in The in the and a the and the and in the the the the found the the in the in the and in and The and a and the the a the in the in the the and the the in the interaction the the the the the interaction and The the and the the in The and the in the the in the and and The protein in in and the the in The in the the and the and the a and the in The in the and a the and the and in the the the the the the interaction domain the and the the the the and and the and and and interaction the and in the domain domain in and and and and in the in the and and domain in The in the and the the domain and a the domain the domain a in the in the the and the the in the in interaction the protein and the kinase kinase The in the domain and in the The domain and the and the domain the interaction and in and in and The in the the the in and and in the the domain interaction the protein the domain the domain domain and in the and The the the in the the and in in and and a domain and in and and interaction and the in the the the The in the domain the interaction in the the The the in the domain the interaction a in interaction The in the in in and and The and the a and in in a interaction and in and a interaction the The in the and in the found in The a interaction the and interaction and in found a interaction and the interaction and interaction and in and the the the a interaction and in and the the The in the the a in protein the in and and and and the protein in in and in in in interaction and in in and the the the in the the in the the in the and and a and in and and a protein in the interaction domain the and the the the the and and the and and and interaction the and in the domain domain in and and and and in the in the and and the the domain and a the domain the domain a in the in the the and the the in the in interaction the protein and the kinase kinase The in the domain and in the The domain and the and the domain the interaction and in and in and The in the the the in and and in the the domain interaction and and a domain and in and and interaction and the in the the the The in the domain the interaction in the the The the in the domain interaction and in and a interaction the The in the and in the found in The a interaction the and interaction and in found a interaction and the interaction and interaction and in and the the the a interaction and in and the the The in the the a in in interaction and in in and the the the in the the in the the in the and and a and in and and a protein in a and and and in a the the protein and and in in the a in a and in the protein the the and The the and a the protein in the a in found the a in the The and The a the and the a the and in and in a the the protein and and in in the a in a and in the protein the the and The the and a the protein in the a in found the a in the The and The a the and the a the and in the the and in the and the the the The The and and The and and the and the and the and the and in and the and the and the in the The the the domain the the in interaction in interaction and in interaction in the in and the and in the and the the the The The and and The and and the and the and the and the and in and the and the and the in the The the the domain the the in interaction in interaction and in interaction in the in and recently the protein-protein in found in a the interaction the and the interaction and the and the The interaction the and in and in the and the and domain the the The and the the a interaction in a interaction a the in and the and the in the the and the in a a and the the and and Bem1p and interaction in the The the the the in the and the the in and in the the and domain a the interaction the domain and and and and and The interaction and in in and in The the interaction in a protein the a protein interaction and the interaction and a domain and in The protein and and and the and in the the protein in and found and a interaction and a kinase The interaction the and the in in and found interaction and in and the the the and a interaction and in the the a and a a the domain and the the and a a and the a a interaction and a interaction and in the in and the in in the and the protein a interaction and and found in in the the the domain domain in domain The recently the protein-protein in found in a the interaction the and the interaction and the and the The interaction the and in and in the and the and The domain the the The and the the a interaction in a interaction a the in and the and the in the the and the in a a and the the and and Bem1p and interaction in the The the the the in the and the the in and in the the and domain a the interaction the domain and and and and and The interaction and in in and in The the interaction in a protein the a protein interaction and The the interaction and a domain and in The protein and and and the and in the the protein in and found and a interaction and a kinase The interaction the and the in in and found interaction and in and the the the and a interaction and in the the a and a a the domain and the the and a a and the a a interaction and a interaction and in the in and the in in the and the protein a interaction and and found in in the the the domain domain in domain and and and

Related Papers

SMART, a simple modular architecture research tool: Identification of signaling domains
Jörg Schultz, Frank Milpetz, Peer Bork et al.|Proceedings of the National Academy of Sciences|1998|3.6k
Biased Probability Monte Carlo Conformational Searches and Electrostatic Calculations for Peptides and Proteins
Ruben Abagyan, Maxim Totrov|Journal of Molecular Biology|1994|987
The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42
Gérard Joberty, Clark Petersen, Lin Gao et al.|Nature Cell Biology|2000|917
The 2.2 Å crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with RaplA and a GTP analogue
Nicolas Nassar, Gudrun Horn, Christian Herrmann et al.|Nature|1995|631
Activation of the Protein Kinase ERK5/BMK1 by Receptor Tyrosine Kinases
Sachiko Kamakura, Tetsuo Moriguchi, Eisuke Nishida|Journal of Biological Chemistry|1999|515