The natural killer cell response and tumor debulking are associated with prolonged survival in recurrent glioblastoma patients receiving dendritic cells loaded with autologous tumor lysates
Serena Pellegatta(Molecular Oncology (United States)), Marica Eoli(Molecular Oncology (United States)), Simona Frigerio(Shanghai Cell Therapy Research Institute), Carlo Antozzi(Institute of Neuroimmunology of the Slovak Academy of Sciences), Maria Grazia Bruzzone(Fondazione IRCCS Istituto Neurologico Carlo Besta), Gabriele Cantini(Molecular Oncology (United States)), Sara Nava(Shanghai Cell Therapy Research Institute), Elena Anghileri(Molecular Oncology (United States)), Lucia Cuppini(Molecular Oncology (United States)), Valeria Cuccarini(Fondazione IRCCS Istituto Neurologico Carlo Besta), Emilio Ciusani(Fondazione IRCCS Istituto Neurologico Carlo Besta), Marta Dossena(Shanghai Cell Therapy Research Institute), Bianca Pollo(Institute of Neuroimmunology of the Slovak Academy of Sciences), Renato Mantegazza(Institute of Neuroimmunology of the Slovak Academy of Sciences), Eugenio Parati(Shanghai Cell Therapy Research Institute), Gaetano Finocchiaro(Molecular Oncology (United States))
Cited by 64Open Access
Abstract
T cells, was significantly associated with prolonged PFS and OS. Patients exhibiting NK-cell responses were characterized by high levels of circulating IFNγ and E4BP4, an NK-cell transcription factor. Furthermore, the NK cell V/B ratio was inversely correlated with the TGFβ2 and VEGF V/B ratios. These results suggest that tumor-loaded DCs may increase the survival rate of patients with recurrent GB after effective tumor debulking, and emphasize the role of the NK-cell response in this therapeutic setting.
Related Papers
No related papers found
Powered by citation graph analysis