Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

John C. Chambers; Diabetes Genetics Replication and Meta-analyses (DIAGRAM+) Study; Weihua Zhang; Joban Sehmi; Man Li; Mark N. Wass; Pim van der Harst; Hilma Hólm; Serena Sanna; Maryam Kavousi; Sebastian E. Baumeister; Lachlan Coin; Guohong Deng; Christian Gieger; Nancy L. Heard‐Costa; Jouke‐Jan Hottenga; Brigitte Kühnel; Vinod Kumar; Vasiliki Lagou; Liming Liang; Jian'an Luan; Pedro Marques‐Vidal; Irene Mateo Leach; Paul F. O’Reilly; John F. Peden; Nilüfer Rahmioğlu; Pasi Soininen; Elizabeth K. Speliotes; Xin Yuan; Guðmar Þorleifsson; Behrooz Z. Alizadeh; Larry D. Atwood; Ingrid B. Borecki; Morris J Brown; Pimphen Charoen; Francesco Cucca; Debashish Das; Eco J. C. de Geus; Anna Dixon; Angela Döring; Georg Ehret; Guðmundur I. Eyjólfsson; Martin Farrall; Nita G. Forouhi; Nele Friedrich; Wolfram Goessling; Daníel F. Guðbjartsson; Tamara B. Harris; Anna‐Liisa Hartikainen; Simon Heath; Gideon M. Hirschfield; Albert Hofman; Georg Homuth; Elina Hyppönen; Harry L.A. Janssen; Toby Johnson; Antti J. Kangas; Ido P. Kema; Jens‐Peter Kühn; Sandra Lai; Mark Lathrop; Markus M. Lerch; Yun Li; T. Jake Liang; Jing‐Ping Lin; Ruth J. F. Loos; Nicholas G. Martin; Miriam F. Moffatt; Grant W. Montgomery; Patricia B. Munroe; Kiran Musunuru; Yusuke Nakamura; Christopher J. O’Donnell; Isleifur Olafsson; Brenda W.J.H. Penninx; Anneli Pouta; Bram P. Prins; Inga Prokopenko; Ralf Puls; Aimo Ruokonen; Markku J. Savolainen; David Schlessinger; Jeoffrey Schouten; Udo Seedorf; Srijita Sen‐Chowdhry; Katherine A. Siminovitch; Johannes H. Smit; Timothy D Spector; Wenting Tan; Tanya M. Teslovich; Taru Tukiainen; André G. Uitterlinden; Melanie M. van der Klauw; Ramachandran S. Vasan; Chris Wallace; Henri Wallaschofski; H‐Erich Wichmann; Gonneke Willemsen; Peter Würtz; Chun Xu; Laura M. Yerges‐Armstrong; Gonçalo R. Abecasis; Kourosh R. Ahmadi; Dorret I Boomsma; Mark J. Caulfield; William Cookson; Cornelia M. van Duijn; Philippe Froguel; Koichi Matsuda; Mark I. McCarthy; Christa Meisinger; Vincent Mooser; Kirsi H. Pietiläinen; Günter Schumann; Harold Snieder; Michael J.E. Sternberg; Ronald P. Stolk; Howard C. Thomas; Unnur Þorsteinsdóttir; Manuela Uda; Gérard Waeber; Nicholas J. Wareham; Dawn Waterworth; Hugh Watkins; John B. Whitfield; Jacqueline C.M. Witteman; Bruce H. R. Wolffenbuttel; Caroline S. Fox; Mika Ala‐Korpela; Kāri Stefánsson; Péter Vollenweider; Henry Völzke; Eric E. Schadt; James Scott; Marjo‐Riitta Järvelin; Paul Elliott; Jaspal S. Kooner

doi:10.1038/ng.970

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

John C. Chambers(National Health Service), Diabetes Genetics Replication and Meta-analyses (DIAGRAM+) Study(Ealing Hospital), Weihua Zhang(Ealing Hospital), Joban Sehmi(Ealing Hospital), Man Li(Royal Brompton Hospital), Mark N. Wass(University Medical Center Groningen), Pim van der Harst(deCODE Genetics (Iceland)), Hilma Hólm(deCODE Genetics (Iceland)), Serena Sanna(Erasmus MC), Maryam Kavousi(Universitätsmedizin Greifswald), Sebastian E. Baumeister(Universitätsmedizin Greifswald), Lachlan Coin(Army Medical University), Guohong Deng(Army Medical University), Christian Gieger(Helmholtz Zentrum München), Nancy L. Heard‐Costa(Boston University), Jouke‐Jan Hottenga(Helmholtz Zentrum München), Brigitte Kühnel(Helmholtz Zentrum München), Vinod Kumar(University Medical Center Groningen), Vasiliki Lagou(University Medical Center Groningen), Liming Liang(Harvard University), Jian'an Luan(Institute of Social and Preventive Medicine), Pedro Marques‐Vidal(University Medical Center Groningen), Irene Mateo Leach(University Medical Center Groningen), Paul F. O’Reilly(Centre for Human Genetics), John F. Peden(Centre for Human Genetics), Nilüfer Rahmioğlu(Centre for Human Genetics), Pasi Soininen(University of Eastern Finland), Elizabeth K. Speliotes(University of Michigan), Xin Yuan(deCODE Genetics (Iceland)), Guðmar Þorleifsson(deCODE Genetics (Iceland)), Behrooz Z. Alizadeh(University Medical Center Groningen), Larry D. Atwood(Boston University), Ingrid B. Borecki(Washington University in St. Louis), Morris J Brown(University of Cambridge), Pimphen Charoen(Mahidol University), Francesco Cucca(Ealing Hospital), Debashish Das(Ealing Hospital), Eco J. C. de Geus(Amsterdam Neuroscience), Anna Dixon(Helmholtz Zentrum München), Angela Döring(Johns Hopkins University), Georg Ehret(Johns Hopkins University), Guðmundur I. Eyjólfsson(Centre for Human Genetics), Martin Farrall(Centre for Human Genetics), Nita G. Forouhi(Universitätsmedizin Greifswald), Nele Friedrich(Brigham and Women's Hospital), Wolfram Goessling(Brigham and Women's Hospital), Daníel F. Guðbjartsson(National Institutes of Health), Tamara B. Harris(National Institutes of Health), Anna‐Liisa Hartikainen(Commissariat à l'Énergie Atomique et aux Énergies Alternatives), Simon Heath(University of Toronto), Gideon M. Hirschfield(University of Toronto), Albert Hofman(Erasmus MC), Georg Homuth(Universität Greifswald), Elina Hyppönen(Erasmus MC), Harry L.A. Janssen(Queen Mary University of London), Toby Johnson(Queen Mary University of London), Antti J. Kangas(University Medical Center Groningen), Ido P. Kema(University Medical Center Groningen), Jens‐Peter Kühn(Universität Greifswald), Sandra Lai(Commissariat à l'Énergie Atomique et aux Énergies Alternatives), Mark Lathrop(Commissariat à l'Énergie Atomique et aux Énergies Alternatives), Markus M. Lerch(University of North Carolina at Chapel Hill), Yun Li(University of North Carolina at Chapel Hill), T. Jake Liang(National Institute of Diabetes and Digestive and Kidney Diseases), Jing‐Ping Lin(National Heart Lung and Blood Institute), Ruth J. F. Loos(QIMR Berghofer Medical Research Institute), Nicholas G. Martin(QIMR Berghofer Medical Research Institute), Miriam F. Moffatt(QIMR Berghofer Medical Research Institute), Grant W. Montgomery(Queen Mary University of London), Patricia B. Munroe(Harvard University), Kiran Musunuru(Boston University), Yusuke Nakamura(The University of Tokyo), Christopher J. O’Donnell(Reykjavík University), Isleifur Olafsson(Reykjavík University), Brenda W.J.H. Penninx(University Medical Center Groningen), Anneli Pouta(University Medical Center Groningen), Bram P. Prins(University Medical Center Groningen), Inga Prokopenko(Centre for Human Genetics), Ralf Puls(Universität Greifswald), Aimo Ruokonen(University of Oulu), Markku J. Savolainen(National Institute on Aging), David Schlessinger(Erasmus MC), Jeoffrey Schouten(Erasmus MC), Udo Seedorf(Imperial College London), Srijita Sen‐Chowdhry(Mount Sinai Hospital), Katherine A. Siminovitch(Mount Sinai Hospital), Johannes H. Smit(King's College London), Timothy D Spector(Army Medical University), Wenting Tan(Army Medical University), Tanya M. Teslovich(University of Michigan), Taru Tukiainen(Erasmus MC), André G. Uitterlinden(University Medical Center Groningen), Melanie M. van der Klauw(Boston University), Ramachandran S. Vasan(Boston University), Chris Wallace(University of Cambridge), Henri Wallaschofski(Universitätsmedizin Greifswald), H‐Erich Wichmann(Helmholtz Zentrum München), Gonneke Willemsen(Amsterdam Public Health), Peter Würtz(Toronto General Hospital), Chun Xu(University of Maryland, Baltimore), Laura M. Yerges‐Armstrong(University of Maryland, Baltimore), Gonçalo R. Abecasis(King's College London), Kourosh R. Ahmadi(King's College London), Dorret I Boomsma(Queen Mary University of London), Mark J. Caulfield(Queen Mary University of London), William Cookson(Erasmus MC), Cornelia M. van Duijn(Hammersmith Hospital), Philippe Froguel(Hammersmith Hospital), Koichi Matsuda(Centre for Human Genetics), Mark I. McCarthy(Centre for Human Genetics), Christa Meisinger(Helmholtz Zentrum München), Vincent Mooser(University of Helsinki), Kirsi H. Pietiläinen(University of Helsinki), Günter Schumann(University Medical Center Groningen), Harold Snieder(University Medical Center Groningen), Michael J.E. Sternberg(University Medical Center Groningen), Ronald P. Stolk(National Health Service), Howard C. Thomas(National Health Service), Unnur Þorsteinsdóttir(deCODE Genetics (Iceland)), Manuela Uda(University Hospital of Lausanne), Gérard Waeber(University Hospital of Lausanne), Nicholas J. Wareham(GlaxoSmithKline (United States)), Dawn Waterworth(Centre for Human Genetics), Hugh Watkins(Centre for Human Genetics), John B. Whitfield(QIMR Berghofer Medical Research Institute), Jacqueline C.M. Witteman(University Medical Center Groningen), Bruce H. R. Wolffenbuttel(Brigham and Women's Hospital), Caroline S. Fox(Brigham and Women's Hospital), Mika Ala‐Korpela(deCODE Genetics (Iceland)), Kāri Stefánsson(deCODE Genetics (Iceland)), Péter Vollenweider(Universitätsmedizin Greifswald), Henry Völzke(Universitätsmedizin Greifswald), Eric E. Schadt(Hammersmith Hospital), James Scott(Hammersmith Hospital), Marjo‐Riitta Järvelin(Finnish Institute for Health and Welfare), Paul Elliott(National Health Service), Jaspal S. Kooner(National Health Service)

Nature Genetics

October 16, 2011

10.1038/ng.970

Cited by 594Open Access

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