Altered sterol composition renders yeast thermotolerant
Luis Caspeta(Chalmers University of Technology), Yun Chen(Chalmers University of Technology), Payam Ghiaci(Chalmers University of Technology), Amir Feizi(Chalmers University of Technology), Steen Buskov(Novozymes (Denmark)), Björn M. Hallström(Science for Life Laboratory), Dina Petranović(Chalmers University of Technology), Jens Nielsen(Novo Nordisk Foundation)
Cited by 449
Abstract
Tricks for boosting yeast's ethanol yields To become a widely used source of fuel, widespread industrial production of ethanol using yeast needs to be simple and efficient. However, two conditions ideal for boosting production—tolerance of higher temperatures and high concentrations of ethanol—have been limiting (see the Perspective by Cheng and Kao). Now, Caspeta et al. have used adaptive laboratory evolution to find yeast strains that can tolerate high temperatures and Lam et al. have identified a route to improve yeast's resistance to high concentrations of ethanol. Science , this issue p. 75 , p. 71 ; see also p. 35
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