Association of TNF2, a TNF-α Promoter Polymorphism, With Septic Shock Susceptibility and Mortality
Jean‐Paul Mira, Alain Cariou(Institut Mondor de Recherche Biomédicale), Franck Grall(Institut Mondor de Recherche Biomédicale), Christophe Delclaux(Institut Mondor de Recherche Biomédicale), Marie-Reine Losser(Institut Mondor de Recherche Biomédicale), Fahrad Heshmati(Institut Mondor de Recherche Biomédicale), Christine Cheval(Institut Mondor de Recherche Biomédicale), Mehran Monchi(Institut Mondor de Recherche Biomédicale), Jean–Louis Teboul(Institut Mondor de Recherche Biomédicale), Florence Riché(Institut Mondor de Recherche Biomédicale), Ghislaine Leleu(Institut Mondor de Recherche Biomédicale), Laurence Arbibe(Institut Mondor de Recherche Biomédicale), Alexandre Mignon(Institut Mondor de Recherche Biomédicale), Marc Delpech(Institut Mondor de Recherche Biomédicale), Jean-François Dhainaut(Institut Mondor de Recherche Biomédicale)
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Abstract
THE PRIMARY cause of death in intensive care units (ICUs).With a mortality rate in excess of 50%, it results in more than 100 000 deaths a year in the United States. 1,2Sepsis-induced organ failure leading to death appears to be due to the activation of a mediator cascade initiated by microbial components. 1,2Although the pathophysiology of systemic inflammation and organ dysfunction is complex, tumor necrosis factor alpha (TNF-␣) has emerged as a proximal and central cytokine of septic shock. 2,3Its administration reproduces essentially all the deleterious effects of endotoxin and bacteria, including
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