Immunomodulation confers herbicide resistance in plants

Kurt C. Almquist(University of Guelph), Yongqing Niu(University of Guelph), Michael D. McLean(University of Guelph), Frank L. Mena(University of Guelph), Kerrm Y. F. Yau(University of Guelph), Kirk Brown(Agriculture and Agri-Food Canada), Jim Brandle(Agriculture and Agri-Food Canada), J. Christopher Hall(University of Guelph)
Plant Biotechnology Journal
February 3, 2004
10.1111/j.1467-7652.2004.00060.x
Cited by 23Open Access
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Abstract

In order to create a novel mechanism for herbicide resistance in plants, we expressed a single-chain antibody fragment (scFv) in tobacco with specific affinity to the auxinic herbicide picloram. Transgenic tobacco plants and seedlings expressing this scFv against picloram were protected from its effect in a dose-dependent manner. This is the first successful use of an antibody to confer in vivo resistance to a low molecular weight xenobiotic (i.e. < 1000 Da). Our results suggest the possibility for a generic antibody-based approach to create crops resistant to low molecular weight xenobiotics for subsequent use in the bioremediation of contaminated soils, crop protection and as novel selectable markers.

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