The role of lipid droplets in metabolic disease in rodents and humans
Andrew S. Greenberg(Jean Mayer Human Nutrition Research Center on Aging), Rosalind Coleman(University of North Carolina at Chapel Hill), Fredric B. Kraemer(VA Palo Alto Health Care System), James L. McManaman(University of Colorado Denver), Martin S. Obin(Tufts University), Vishwajeet Puri(Boston University), Qing-Wu Yan(Jean Mayer Human Nutrition Research Center on Aging), Hideaki Miyoshi(Hokkaido University), Douglas G. Mashek(University of Minnesota)
Cited by 619Open Access
Abstract
Lipid droplets (LDs) are intracellular organelles that store neutral lipids within cells. Over the last two decades there has been a dramatic growth in our understanding of LD biology and, in parallel, our understanding of the role of LDs in health and disease. In its simplest form, the LD regulates the storage and hydrolysis of neutral lipids, including triacylglycerol and/or cholesterol esters. It is becoming increasingly evident that alterations in the regulation of LD physiology and metabolism influence the risk of developing metabolic diseases such as diabetes. In this review we provide an update on the role of LD-associated proteins and LDs in metabolic disease.
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