A recent bottleneck of Y chromosome diversity coincides with a global change in culture
Monika Karmin(Estonian Biocentre), Lauri Saag(Estonian Biocentre), Mário Vicente(University of Cambridge), Melissa A. Wilson Sayres(University of California, Berkeley), Mari Järve(Estonian Biocentre), Ulvi Gerst Talas(University of Tartu), Siiri Rootsi(Estonian Biocentre), Anne-Mai IlumäE(Estonian Biocentre), Reedik Mägi(Estonian Biocentre), Mario Mitt(University of Tartu), Luca Pagani(University of Cambridge), Tarmo Puurand(University of Tartu), Zuzana Faltyskova(University of Cambridge), Florian Clemente(University of Cambridge), Alexia Cardona(University of Cambridge), Ene Metspalu(Estonian Biocentre), Hovhannes Sahakyan(Estonian Academy of Sciences), Bayazit Yunusbayev(Russian Academy of Sciences), Georgi Hudjashov(University of Auckland), Michael DeGiorgio(Pennsylvania State University), Eva‐Liis Loogväli(Estonian Biocentre), Christina Eichstaedt(University of Cambridge), Mikk Eelmets(Estonian Biocentre), Gyaneshwer Chaubey(Estonian Biocentre), Kristiina Tambets(Estonian Biocentre), Sergei Litvinov(Russian Academy of Sciences), Maru Mormina(University of Winchester), Yali Xue(Wellcome Sanger Institute), Qasim Ayub(Wellcome Sanger Institute), G. Zoraqi(University of Medicine Tirana), Thorfinn Sand Korneliussen(University of Copenhagen), Farida Akhatova(Bashkir State University), Joseph Lachance(Georgia Institute of Technology), Sarah A. Tishkoff(University of Pennsylvania), К. Т. Момыналиев(Western Laboratories (United States)), François‐Xavier Ricaut(Université Fédérale de Toulouse Midi-Pyrénées), Pradiptajati Kusuma(Université Fédérale de Toulouse Midi-Pyrénées), Harilanto Razafindrazaka(Université Fédérale de Toulouse Midi-Pyrénées), Denis Pierron(Université Fédérale de Toulouse Midi-Pyrénées), Murray P. Cox(Massey University), Gazi Nurun Nahar Sultana(University of Dhaka), Rane Willerslev(Aarhus University), Craig Muller(University of Copenhagen), Michael Westaway(Griffith University), David M. Lambert(Griffith University), Vedrana Škaro(Genos (Croatia)), Lejla Kovačević(Centogene (Germany)), Shahlo Тurdikulova(Academy of Sciences Republic of Uzbekistan), Dilbar Dalimova(Academy of Sciences Republic of Uzbekistan), Р. И. Хусаинова(Russian Academy of Sciences), Natalya Trofimova(Russian Academy of Sciences), В. Р. Ахметова(Russian Academy of Sciences), I. M. Khidiyatova(Russian Academy of Sciences), Daria V. Lichman(Institute of Cytology and Genetics), Jainagul Isakova(National Academy of Sciences of the Republic of Kyrgyzstan), Elvira Pocheshkhova(Kuban State Medical University), Zhaxylyk Sabitov(L. N. Gumilyov Eurasian National University), Nikolay A. Barashkov(North-Eastern Federal University), Pagbajabyn Nymadawa(Mongolian Academy of Sciences), Evelin Mihailov(Estonian Biocentre), Joseph Wee Tien Seng(National Cancer Centre Singapore), Irina Evseeva(Anthony Nolan), Andrea Bamberg Migliano(University College London), Syafiq Abdullah(Raja Isteri Pengiran Anak Saleha Hospital), George Andriadze(Caucasus University), Dragan Primorac(Pennsylvania State University), Л. А. Атраментова(V. N. Karazin Kharkiv National University), Olga Utevska(V. N. Karazin Kharkiv National University), Levon Yepiskoposyan(Institute of Molecular Biology), Damir Marjanović(Genos (Croatia)), Alena Kushniarevich(Estonian Academy of Sciences), Doron M. Behar(Estonian Biocentre), Christian Gilissen(Radboud University Nijmegen), Lisenka E.L.M. Vissers(Radboud University Nijmegen), Joris A. Veltman(Radboud University Nijmegen), Elena Balanovska(Russian Academy of Sciences), М. В. Деренко(Russian Academy of Sciences), B. А. Malyarchuk(Russian Academy of Sciences), Andres Metspalu(Estonian Biocentre), С.А. Федорова(North-Eastern Federal University), Anders Eriksson(University of Cambridge), Andrea Manica(University of Cambridge), Fernando L. Méndez(Stanford University), Tatiana M. Karafet(University of Arizona), Krishna R. Veeramah(Stony Brook University), Neil Bradman(Sir Halley Stewart Trust), Michael F. Hammer(University of Arizona), L. P. Osipova(Institute of Cytology and Genetics), Oleg Balanovsky(Russian Academy of Sciences), Э. К. Хуснутдинова(Russian Academy of Sciences), Knut Johnsen(University Hospital of North Norway), Maido Remm(University of Tartu), Mark Thomas(University College London), Chris Tyler‐Smith(Wellcome Sanger Institute), Peter A. Underhill(Stanford University), Eske Willerslev(University of Copenhagen), Rasmus Nielsen(University of California, Berkeley), Mait Metspalu(Estonian Biocentre), Richard Villems(Estonian Academy of Sciences), Toomas Kivisild(University of Cambridge)
Cited by 501Open Access
Abstract
It is commonly thought that human genetic diversity in non-African populations was shaped primarily by an out-of-Africa dispersal 50-100 thousand yr ago (kya). Here, we present a study of 456 geographically diverse high-coverage Y chromosome sequences, including 299 newly reported samples. Applying ancient DNA calibration, we date the Y-chromosomal most recent common ancestor (MRCA) in Africa at 254 (95% CI 192-307) kya and detect a cluster of major non-African founder haplogroups in a narrow time interval at 47-52 kya, consistent with a rapid initial colonization model of Eurasia and Oceania after the out-of-Africa bottleneck. In contrast to demographic reconstructions based on mtDNA, we infer a second strong bottleneck in Y-chromosome lineages dating to the last 10 ky. We hypothesize that this bottleneck is caused by cultural changes affecting variance of reproductive success among males.
Related Papers
No related papers found
Powered by citation graph analysis