Physicochemical Properties and Cellular Toxicity of Nanocrystal Quantum Dots Depend on Their Surface Modification
Akiyoshi Hoshino(National Institute of Infectious Diseases), Kouki Fujioka(National Institute of Infectious Diseases), Taisuke Oku(National Institute of Infectious Diseases), Masakazu Suga(National Institute of Infectious Diseases), Yu Sasaki(National Institute of Infectious Diseases), Toshihiro Ohta(National Institute of Infectious Diseases), Masato Yasuhara(National Institute of Infectious Diseases), Kazuo Suzuki(National Institute of Infectious Diseases), Kenji Yamamoto(National Institute of Infectious Diseases)
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Abstract
Nanocrystal quantum dots (QDs) have been applied to molecular biology because of their greater and longer fluorescence. Here we report the potential cytotoxicity of our characterized QDs modified with various molecules. Surface modification of QDs changed their physicochemical properties. In addition, the cytotoxicity of QDs was dependent on their surface molecules. These results suggested that the properties of QDs are not related to those of QD-core materials but to molecules covering the surface of QDs.
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