Diketopyrrolopyrrole‐Porphyrin Conjugates with High Two‐Photon Absorption and Singlet Oxygen Generation for Two‐Photon Photodynamic Therapy
Julie Schmitt(Centre National de la Recherche Scientifique), Valérie Heitz(Centre National de la Recherche Scientifique), Angélique Sour(Centre National de la Recherche Scientifique), Frédéric Bolze(Centre National de la Recherche Scientifique), Hussein Ftouni(Centre National de la Recherche Scientifique), Jean‐François Nicoud(Centre National de la Recherche Scientifique), Lucia Flamigni(Institute of Organic Synthesis and Photoreactivity), Barbara Ventura(Centre National de la Recherche Scientifique)
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Abstract
Two-photon photodynamic therapy is a promising therapeutic method which requires the development of sensitizers with efficient two-photon absorption and singlet-oxygen generation. Reported here are two new diketopyrrolopyrrole-porphyrin conjugates as robust two-photon absorbing dyes with high two-photon absorption cross-sections within the therapeutic window. Furthermore, for the first time the singlet-oxygen generation efficiency of diketopyrrolopyrrole-containing systems is investigated. A preliminary study on cell culture showed efficient two-photon induced phototoxicity.
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