Transcriptional and Translational Control in the Mammalian Unfolded Protein Response

Heather P. Harding(New York University), Marcella A. Calfon(New York University), Fumihiko Urano(New York University), Isabel Novoa(New York University), David Ron(New York University)
Annual Review of Cell and Developmental Biology
October 7, 2002
10.1146/annurev.cellbio.18.011402.160624
Cited by 915

Abstract

Cells monitor the physiological load placed on their endoplasmic reticulum (ER) and respond to perturbations in ER function by a process known as the unfolded protein response (UPR). In metazoans the UPR has a transcriptional component that up-regulates expression of genes that enhance the capacity of the organelle to deal with the load of client proteins and a translational component that insures tight coupling between protein biosynthesis on the cytoplasmic side and folding in the ER lumen. Together, these two components adapt the secretory apparatus to physiological load and protect cells from the consequences of protein malfolding.

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