A Computer Program for Aligning a cDNA Sequence with a Genomic DNA Sequence
Liliana Florea(Pennsylvania State University), George Hartzell(Pennsylvania State University), Zheng Zhang(Pennsylvania State University), Gerald M. Rubin(Pennsylvania State University), Webb Miller(Pennsylvania State University)
Cited by 728Open Access
Abstract
We address the problem of efficiently aligning a transcribed and spliced DNA sequence with a genomic sequence containing that gene, allowing for introns in the genomic sequence and a relatively small number of sequencing errors. A freely available computer program, described herein, solves the problem for a 100-kb genomic sequence in a few seconds on a workstation.
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