In depth analysis of the in vivo toxicity of nanoparticles of porous iron(iii) metal–organic frameworks
Tarek Baâti(Institut Lavoisier de Versailles), Leïla Njim(University of Monastir), Fadoua Neffati(University of Monastir), Abdelhamid Kerkeni(University of Monastir), Muriel Bouttemi(Université de Versailles Saint-Quentin-en-Yvelines), Ruxandra Gref(Université Paris Cité), Mohamed Fadhel Najjar(University of Monastir), Abdelfateh Zakhama(University of Monastir), Patrick Couvreur(Centre National de la Recherche Scientifique), Christian Serre(Institut Lavoisier de Versailles), Patricia Horcajada(Centre National de la Recherche Scientifique)
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Abstract
In vivo acute toxicity of high doses of nanoparticles of three different porous iron(III) carboxylate Metal–Organic Frameworks (nanoMOFs) was intravenously investigated in rats by evaluating their distribution, metabolism and excretion. All studied parameters (serum, enzymatic, histological, etc.) are in agreement with a low acute toxicity. The mechanism of degradation and excretion of the nanoMOFs has been evidenced and shows that the nanoparticles are rapidly sequestered by the liver and spleen, then further biodegraded and directly eliminated in urine or feces without metabolization and substantial toxicity.
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