Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

Athena Hadjixenofontos; Ashley Beecham; Jacob L. McCauley; Clara P. Manrique; Margaret A Pericak‐Vance; Ioanna Konidari; Nikolaos A Patsopoulos; Philip L. De Jager; Michelle Lee; Irene Y. Frohlich; Nikolaos A. Patsopoulos; Nikolaos A Patsopoulos; Philip De Jager; Nikolaos A Patsopoulos; Nikolaos A Patsopoulos; Céline Bellenguez; Colin Freeman; Alexander Dilthey; Dionysia K. Xifara; Gavin Band; Peter Donnelly; Chris C. A. Spencer; Loukas Moutsianas; Amy Strange; Matti Pirinen; Gil McVean; Mary F. Davis; Nathalie Schnetz‐Boutaud; Jonathan L. Haines; Alastair Compston; Barnaby Fiddes; Stephen Sawcer; Anu Kemppinen; Maria Ban; Amie Baker; David Hafler; Chris Cotsapas; Philip De Jager; Cristin McCabe; Chris Cotsapas; David A. Hafler; Chris Cotsapas; Carl A. Anderson; Jeffrey C. Barrett; Sarah Hunt; Sarah Edkins; Panos Deloukas; Tejas Shah; Hannah Blackburn; Cordelia Langford; Robert Andrews; David J. Booth; Steve Vucic; Graeme J. Stewart; Leentje Cosemans; An Goris; Bénédicte Dubois; Annette Oturai; Per Soelberg Sørensen; Helle Bach Søndergaard; Finn Sellebjerg; Janna Saarela; Virpi Leppä; Isabelle Cournu‐Rebeix; Bertrand Fontaine; Vincent Damotte; Angela Jochim; Bernhard Hemmer; Muni Hoshi; Achim Berthele; Thomas Korn; Rebecca Selter; Viola Biberacher; Juliane Winkelmann; Verena Grummel; Helena Kronsbein; Dorothea Buck; Bernhard Hemmer; Juliane Winkelmann; Bernhard Hemmer; Claes Martin; Volker Siffrin; Frauke Zipp; Felix Luessi; Christina M Lill; Christiane Graetz; Eva Zindler; Nadia Barizzone; Lucia Corrado; Sandra D’Alfonso; Laura Bergamaschi; Nadia Barizzone; Lucia Corrado; Sandra D’Alfonso; Laura Bergamaschi; Filippo Martinelli-Boneschi; Melissa Sorosina; Paola Brambilla; Giuseppe Liberatore; Giancarlo Comi; Federica Esposito; Clara Guaschino; Giuseppe Liberatore; Filippo Martinelli-Boneschi; Vittorio Martinelli; Giancarlo Comi; Federica Esposito; Mariaemma Rodegher; Clara Guaschino; Bruce Taylor; Elisabeth Gulowsen Celius; Inger‐Lise Mero; Hanne F. Harbo; Inger‐Lise Mero; Benedicte A. Lie; Hanne F. Harbo; Magdalena Lindén; Helga Westerlind; Jan Hillert; Jenny Link; Maja Jagodic; Ingrid Kockum; Tomas Olsson; Izaura Lima Bomfim; Lou Brundin; Fredrik Piehl; Emilie Sundqvist; Stacy J. Caillier; Jorge R. Oksenberg; Bruce Cree; Sergio E. Baranzini; Pierre‐Antoine Gourraud; Stephen L. Hauser; Julia Mescheriakova; Rogier Hintzen; Lisa F. Barcellos; Hong Quach; Lisa F. Barcellos; Catherine Schaefer; Ling Shen; Lisa F. Barcellos; Cristina Agliardi; Lars Alfredsson; Mehdi Alizadeh; Luisa Bernardinelli; Thomas M. C. Binder; Simon Broadley; Bruno Brochet; Helmut Butzkueven; Helmut Butzkueven; William Camu; Wassila Carpentier; Paola Cavalla; Paola Cavalla; Irène Coman; Daniele Cusi; Gilles Defer; Silvia Delgado; Alessia Di Sapio; Martin Duddy; Irina Elovaara; Nikos Evangelou; Judith Field; James S. Wiley; André Franke; Daniela Galimberti; Daniela Galimberti; Christian Gieger; Andrew Graham; Håkon Håkonarson; Håkon Håkonarson; Christopher Halfpenny; Gillian Hall; Per Hall; Anders Hamsten; James Harley; Timothy Harrower; Clive Hawkins; Garrett Hellenthal; Charles Hillier; John Zajicek; Jeremy Hobart; Roland Martin; Ilijas Jelčić; Mireia Sospedra; Roland Martin; Ilijas Jelčić; Mireia Sospedra; B. Kendall; Allan G. Kermode; Allan G. Kermode; Trevor J. Kilpatrick; Keijo Koivisto; Malin Larsson; Mark Lathrop; Mark Lathrop; Mark Lathrop; Christine Lebrun‐Frénay; Jeannette Lechner‐Scott; Maurizio Leone; Inger‐Lise Mero; Benedicte A. Lie; Christina M Lill; Jan Lycke; Fabìo Macciardi; Fabìo Macciardi; Satu Männistö; Deborah Mason; Gordon Mazibrada; Kjell‐Morten Myhr; Guy Nagels; Richard Nicholas; Petra Nilsson; Siân Price; Mauri Reunanen; Mauri Reunanen; Vincent Thijs; Wim Robberecht; Vincent Thijs; Wim Robberecht; Vincent Thijs; Wim Robberecht; Neil P. Robertson; David Rog; Marco Salvetti; Sandip Shaunak; Simon Shields; Mark Slee; Anne Spurkland; John Thorpe; Anna Ticca; Pentti J. Tienari; Cornelia M. van Duijn; Elizabeth Visser; Alastair Wilkins; James F. Wilson; Juliane Winkelmann; Juliane Winkelmann; Adrian J. Ivinson; David Hafler

doi:10.1038/ng.2770

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

Athena Hadjixenofontos(University of Miami), Ashley Beecham(Broad Institute), Jacob L. McCauley(University of Miami), Clara P. Manrique(University of Miami), Margaret A Pericak‐Vance(University of Miami), Ioanna Konidari(Broad Institute), Nikolaos A Patsopoulos(Broad Institute), Philip L. De Jager(Broad Institute), Michelle Lee(Brigham and Women's Hospital), Irene Y. Frohlich(Brigham and Women's Hospital), Nikolaos A. Patsopoulos(Broad Institute), Nikolaos A Patsopoulos(Broad Institute), Philip De Jager(Broad Institute), Nikolaos A Patsopoulos (Broad Institute), Nikolaos A Patsopoulos(Broad Institute), Céline Bellenguez(Centre for Human Genetics), Colin Freeman(Università degli Studi del Piemonte Orientale “Amedeo Avogadro”), Alexander Dilthey(Centre for Human Genetics), Dionysia K. Xifara(University of Tasmania), Gavin Band(Centre for Human Genetics), Peter Donnelly(Centre for Human Genetics), Chris C. A. Spencer(Centre for Human Genetics), Loukas Moutsianas(Centre for Human Genetics), Amy Strange(Centre for Human Genetics), Matti Pirinen(Centre for Human Genetics), Gil McVean(Centre for Human Genetics), Mary F. Davis(QB3), Nathalie Schnetz‐Boutaud(Center for Human Genetics), Jonathan L. Haines(Karolinska Institutet), Alastair Compston(University of Cambridge), Barnaby Fiddes(Michigan Technological University), Stephen Sawcer(University of Cambridge), Anu Kemppinen(University of Copenhagen), Maria Ban(University of Cambridge), Amie Baker(University of Cambridge), David Hafler (Broad Institute), Chris Cotsapas(Broad Institute), Philip De Jager(Broad Institute), Cristin McCabe(Broad Institute), Chris Cotsapas(Broad Institute), David A. Hafler(Broad Institute), Chris Cotsapas(Broad Institute), Carl A. Anderson(Wellcome Sanger Institute), Jeffrey C. Barrett(Universität Hamburg), Sarah Hunt(Wellcome Sanger Institute), Sarah Edkins(Wellcome Sanger Institute), Panos Deloukas(Wellcome Sanger Institute), Tejas Shah(Griffith University), Hannah Blackburn(Université de Bordeaux), Cordelia Langford(Wellcome Sanger Institute), Robert Andrews(Wellcome Sanger Institute), David J. Booth(The University of Sydney), Steve Vucic(The University of Sydney), Graeme J. Stewart(The University of Sydney), Leentje Cosemans(Sorbonne Université), An Goris(University of Turin), Bénédicte Dubois(University of Oslo), Annette Oturai(Copenhagen University Hospital), Per Soelberg Sørensen(Copenhagen University Hospital), Helle Bach Søndergaard(Università degli Studi del Piemonte Orientale “Amedeo Avogadro”), Finn Sellebjerg(Copenhagen University Hospital), Janna Saarela(University of Helsinki), Virpi Leppä(University of Helsinki), Isabelle Cournu‐Rebeix(Inserm), Bertrand Fontaine(Inserm), Vincent Damotte(Inserm), Angela Jochim(University of Miami), Bernhard Hemmer(Wellcome Sanger Institute), Muni Hoshi(TUM Klinikum), Achim Berthele(TUM Klinikum), Thomas Korn(TUM Klinikum), Rebecca Selter(TUM Klinikum), Viola Biberacher(TUM Klinikum), Juliane Winkelmann(TUM Klinikum), Verena Grummel(Tampere University), Helena Kronsbein(TUM Klinikum), Dorothea Buck(Nottingham University Hospitals NHS Trust), Bernhard Hemmer (University of Cambridge), Juliane Winkelmann(The University of Melbourne), Bernhard Hemmer(TUM Klinikum), Claes Martin(Karolinska Institutet), Volker Siffrin(Johannes Gutenberg University Mainz), Frauke Zipp(University of Milan), Felix Luessi(Johannes Gutenberg University Mainz), Christina M Lill(University of California, San Francisco), Christiane Graetz(Johannes Gutenberg University Mainz), Eva Zindler(National Health Service), Nadia Barizzone(Università degli Studi del Piemonte Orientale “Amedeo Avogadro”), Lucia Corrado(Università degli Studi del Piemonte Orientale “Amedeo Avogadro”), Sandra D’Alfonso(Università degli Studi del Piemonte Orientale “Amedeo Avogadro”), Laura Bergamaschi (Università degli Studi del Piemonte Orientale “Amedeo Avogadro”), Nadia Barizzone(Università degli Studi del Piemonte Orientale “Amedeo Avogadro”), Lucia Corrado(Università degli Studi del Piemonte Orientale “Amedeo Avogadro”), Sandra D’Alfonso(Università degli Studi del Piemonte Orientale “Amedeo Avogadro”), Laura Bergamaschi (Università degli Studi del Piemonte Orientale “Amedeo Avogadro”), Filippo Martinelli-Boneschi(Vita-Salute San Raffaele University), Melissa Sorosina(Vita-Salute San Raffaele University), Paola Brambilla(Vita-Salute San Raffaele University), Giuseppe Liberatore(Vita-Salute San Raffaele University), Giancarlo Comi(Vita-Salute San Raffaele University), Federica Esposito(Vita-Salute San Raffaele University), Clara Guaschino(Vita-Salute San Raffaele University), Giuseppe Liberatore(Vita-Salute San Raffaele University), Filippo Martinelli-Boneschi(Vita-Salute San Raffaele University), Vittorio Martinelli(Universität Hamburg), Giancarlo Comi(Vita-Salute San Raffaele University), Federica Esposito(Vita-Salute San Raffaele University), Mariaemma Rodegher(Murdoch University), Clara Guaschino(Vita-Salute San Raffaele University), Bruce Taylor(University of Tasmania), Elisabeth Gulowsen Celius(Oslo University Hospital), Inger‐Lise Mero(Oslo University Hospital), Hanne F. Harbo(Oslo University Hospital), Inger‐Lise Mero(Oslo University Hospital), Benedicte A. Lie(Linköping University), Hanne F. Harbo(Oslo University Hospital), Magdalena Lindén(Karolinska Institutet), Helga Westerlind(Karolinska Institutet), Jan Hillert(Harvard University Press), Jenny Link(Karolinska Institutet), Maja Jagodic(University of Helsinki), Ingrid Kockum(Karolinska Institutet), Tomas Olsson(University of Oslo), Izaura Lima Bomfim(Max Planck Society), Lou Brundin(Karolinska Institutet), Fredrik Piehl(Karolinska Institutet), Emilie Sundqvist(Johannes Gutenberg University Mainz), Stacy J. Caillier(University of California, San Francisco), Jorge R. Oksenberg(University of California, San Francisco), Bruce Cree(University of California, San Francisco), Sergio E. Baranzini(University of Miami), Pierre‐Antoine Gourraud(Universität Hamburg), Stephen L. Hauser(University of California, San Francisco), Julia Mescheriakova(Erasmus MC), Rogier Hintzen(University Hospitals Birmingham NHS Foundation Trust), Lisa F. Barcellos(QB3), Hong Quach(University of Oslo), Lisa F. Barcellos(QB3), Catherine Schaefer(Kaiser Permanente), Ling Shen(Kaiser Permanente), Lisa F. Barcellos(QB3), Cristina Agliardi(Don Carlo Gnocchi Foundation), Lars Alfredsson(Lund University), Mehdi Alizadeh(Karolinska Institutet), Luisa Bernardinelli(University of Oxford), Thomas M. C. Binder(Universität Hamburg), Simon Broadley(Griffith University), Bruno Brochet(Centre Hospitalier Universitaire de Bordeaux), Helmut Butzkueven(Box Hill Hospital), Helmut Butzkueven(Box Hill Hospital), William Camu(Centre Hospitalier Universitaire de Montpellier), Wassila Carpentier(Inserm), Paola Cavalla(Azienda Ospedaliera Citta' della Salute e della Scienza di Torino), Paola Cavalla(Azienda Ospedaliera Citta' della Salute e della Scienza di Torino), Irène Coman(University of Copenhagen), Daniele Cusi(Ospedale San Paolo), Gilles Defer(Kaiser Permanente), Silvia Delgado(University of Miami), Alessia Di Sapio(Kaiser Permanente), Martin Duddy(Royal Victoria Infirmary), Irina Elovaara(Johannes Gutenberg University Mainz), Nikos Evangelou(University of Nottingham), Judith Field(University of Copenhagen), James S. Wiley(The University of Melbourne), André Franke(Universität Hamburg), Daniela Galimberti(University of Oslo), Daniela Galimberti(University of Milan), Christian Gieger(Karolinska Institutet), Andrew Graham(Ipswich Hospital), Håkon Håkonarson(Children's Hospital of Philadelphia), Håkon Håkonarson(Children's Hospital of Philadelphia), Christopher Halfpenny(University of Helsinki), Gillian Hall(Aberdeen Royal Infirmary), Per Hall(University of Aberdeen), Anders Hamsten(The University of Sydney), James Harley(Hull Royal Infirmary), Timothy Harrower(The University of Melbourne), Clive Hawkins(Royal Stoke University Hospital), Garrett Hellenthal(University College London), Charles Hillier(Poole Hospital), John Zajicek(Peninsula College of Medicine and Dentistry), Jeremy Hobart(Johannes Gutenberg University Mainz), Roland Martin (Universität Hamburg), Ilijas Jelčić(University of Miami), Mireia Sospedra(Universität Hamburg), Roland Martin (The University of Sydney), Ilijas Jelčić(Broad Institute), Mireia Sospedra(Universität Hamburg), B. Kendall(University of Cambridge), Allan G. Kermode(Murdoch University), Allan G. Kermode(Broad Institute), Trevor J. Kilpatrick(The University of Melbourne), Keijo Koivisto(University of Miami), Malin Larsson(Linköping University), Mark Lathrop(Fondation Jean Dausset-CEPH), Mark Lathrop(Fondation Jean Dausset-CEPH), Mark Lathrop(Fondation Jean Dausset-CEPH), Christine Lebrun‐Frénay(Hôpital Pasteur), Jeannette Lechner‐Scott(Hunter Medical Research Institute), Maurizio Leone(Ospedale Maggiore), Inger‐Lise Mero(Oslo University Hospital), Benedicte A. Lie(Oslo University Hospital), Christina M Lill(Johannes Gutenberg University Mainz), Jan Lycke(University of Gothenburg), Fabìo Macciardi(University of Milan), Fabìo Macciardi(University of Milan), Satu Männistö(Finnish Institute for Health and Welfare), Deborah Mason(Canterbury District Health Board), Gordon Mazibrada(Queen Elizabeth Hospital Birmingham), Kjell‐Morten Myhr(Haukeland University Hospital), Guy Nagels, Richard Nicholas(Charing Cross Hospital), Petra Nilsson(Lund University), Siân Price(Royal Hallamshire Hospital), Mauri Reunanen(Oulu University Hospital), Mauri Reunanen(Oulu University Hospital), Vincent Thijs(KU Leuven), Wim Robberecht(KU Leuven), Vincent Thijs(KU Leuven), Wim Robberecht(KU Leuven), Vincent Thijs(KU Leuven), Wim Robberecht(KU Leuven), Neil P. Robertson(University Hospital of Wales), David Rog(Salford Royal NHS Foundation Trust), Marco Salvetti(Sapienza University of Rome), Sandip Shaunak(Royal Preston Hospital), Simon Shields(Norfolk and Norwich University Hospital), Mark Slee(Flinders University), Anne Spurkland(University of Oslo), John Thorpe(Peterborough City Hospital), Anna Ticca(ATS Sardegna (Italy)), Pentti J. Tienari(University of Helsinki), Cornelia M. van Duijn(Erasmus MC), Elizabeth Visser(University of Aberdeen), Alastair Wilkins(Frenchay Hospital), James F. Wilson(University of Edinburgh), Juliane Winkelmann(TUM Klinikum), Juliane Winkelmann(TUM Klinikum), Adrian J. Ivinson(Harvard NeuroDiscovery Center), David Hafler(Broad Institute)

Nature Genetics

September 29, 2013

10.1038/ng.2770

Cited by 1,439Open Access

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