Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways

Lisette Stolk; John R. B. Perry; Daniel I. Chasman; Chunyan He; Massimo Mangino; Patrick Sulem; Maja Barbalić; Linda Broer; Enda M. Byrne; Florian Ernst; Tõnu Esko; Nora Franceschini; Daníel F. Guðbjartsson; Jouke‐Jan Hottenga; Peter Kraft; Patrick F. McArdle; Eleonora Porcu; So-Youn Shin; Albert V. Smith; S. van Wingerden; Guangju Zhai; Wei Zhuang; Eva Albrecht; Behrooz Z. Alizadeh; Thor Aspelund; Stefania Bandinelli; Lovorka Barać Lauc; J. Beckmann; Mladen Boban; Eric Boerwinkle; Frank J. Broekmans; Andrea Burri; Harry Campbell; Stephen J. Chanock; Constance Chen; Marilyn C. Cornelis; Tanguy Corre; Andrea D. Coviello; Pio D’Adamo; Gail Davies; Ulf dé Fairé; Eco J. C. de Geus; Ian J. Deary; George V Z Dedoussis; Panagiotis Deloukas; Shah Ebrahim; Guðný Eiríksdóttir; Valur Emilsson; Johan G. Eriksson; Bart C.J.M. Fauser; Liana Ferreli; Luigi Ferrucci; Krista Fischer; Aaron R. Folsom; Melissa E. Garcia; Paolo Gasparini; Christian Gieger; Nicole L. Glazer; Diederick E. Grobbee; Per Hall; Toomas Haller; Susan E. Hankinson; Merli Hass; Caroline Hayward; Andrew C. Heath; Albert Hofman; Erik Ingelsson; A. Cecile J.W. Janssens; Andrew D. Johnson; David Karasik; Sharon L. R. Kardia; Jules J. Keyzer; Douglas P. Kiel; Ivana Kolčić; Zoltán Kutalik; Jari Lahti; Sandra Lai; Triin Laisk; Joop S.E. Laven; Debbie A. Lawlor; Jianjun Liu; Lorna M. Lopez; Yvonne V. Louwers; Patrik K. E. Magnusson; Mara Marongiu; Nicholas G. Martin; Irena Martinović Klarić; Corrado Masciullo; Barbara McKnight; Sarah E. Medland; David Melzer; Vincent Mooser; Pau Navarro; Anne B. Newman; Dale R. Nyholt; N. Charlotte Onland‐Moret; Aarno Palotie; Guillaume Paré; Alex Parker; Nancy L. Pedersen; Petra H. Peeters; Giorgio Pistis; Andrew Plump; Ozren Polašek; Victor J.M. Pop; Bruce M. Psaty; Katri Räikkönen; Emil Rehnberg; Jerome I. Rotter; Igor Rudan; Cinzia Sala; Andres Salumets; Angelo Scuteri; Andrew B. Singleton; Jennifer A. Smith; Harold Snieder; Nicole Soranzo; Simon Stacey; John M. Starr; Maria G. Stathopoulou; Kathleen Stirrups; Ronald P. Stolk; Unnur Styrkársdóttir; Yan V. Sun; Albert Tenesa; Barbara Thorand; Daniela Toniolo; Laufey Tryggvadóttír; Kim Tsui; Sheila Ulivi; Rob M. van Dam; Yvonne T. van der Schouw; Carla H. van Gils; Peter van Nierop; Jacqueline M. Vink; Peter M. Visscher; Marlies Voorhuis; Gérard Waeber; Henri Wallaschofski; H.‐Erich Wichmann; Elisabeth Widén; Colette J.M. Wijnands-van Gent; Gonneke Willemsen; James F. Wilson; Bruce H. R. Wolffenbuttel; Alan F. Wright; Laura M. Yerges-Armstrong; Tatijana Zemunik; Lina Zgaga; M. Carola Zillikens; Marek Zygmunt; The LifeLines Cohort Study; Alice M. Arnold; Dorret I Boomsma; Julie E. Buring; Laura Crisponi; Ellen W. Demerath; Vilmundur Guðnason; Tamara B. Harris; Frank B. Hu; David J. Hunter; Lenore J. Launer; Andres Metspalu; Grant W. Montgomery; Ben A. Oostra; Paul M. Ridker; Serena Sanna; David Schlessinger; Tim D. Spector; Kari Stefansson; Elizabeth A. Streeten; Unnur Thorsteinsdottir; Manuela Uda; André G. Uitterlinden; Cornelia M. van Duijn; Henry Völzke; Anna Murray; Joanne M. Murabito; Jenny A. Visser; Kathryn L. Lunetta

doi:10.1038/ng.1051

Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways

Lisette Stolk(Erasmus MC), John R. B. Perry(University of Exeter), Daniel I. Chasman(Brigham and Women's Hospital), Chunyan He(Indiana University School of Medicine), Massimo Mangino(King's College London), Patrick Sulem(deCODE Genetics (Iceland)), Maja Barbalić(The University of Texas Health Science Center at Houston), Linda Broer(Erasmus MC), Enda M. Byrne(QIMR Berghofer Medical Research Institute), Florian Ernst(Universität Greifswald), Tõnu Esko(University of Tartu), Nora Franceschini(University of North Carolina at Chapel Hill), Daníel F. Guðbjartsson(deCODE Genetics (Iceland)), Jouke‐Jan Hottenga(Vrije Universiteit Amsterdam), Peter Kraft(Harvard University), Patrick F. McArdle(University of Maryland, Baltimore), Eleonora Porcu(Institute of Genetic and Biomedical Research), So-Youn Shin(Wellcome Sanger Institute), Albert V. Smith(Icelandic Heart Association), S. van Wingerden(Erasmus MC), Guangju Zhai(King's College London), Wei Zhuang(Boston University), Eva Albrecht(Helmholtz Zentrum München), Behrooz Z. Alizadeh(University Medical Center Groningen), Thor Aspelund(Icelandic Heart Association), Stefania Bandinelli(Azienda Sanitaria di Firenze), Lovorka Barać Lauc(Croatian Science Foundation), J. Beckmann(University of Lausanne), Mladen Boban(University of Split), Eric Boerwinkle(The University of Texas Health Science Center at Houston), Frank J. Broekmans(University Medical Center Utrecht), Andrea Burri(King's College London), Harry Campbell(University of Edinburgh), Stephen J. Chanock(National Institutes of Health), Constance Chen(Harvard University), Marilyn C. Cornelis(Harvard University), Tanguy Corre, Andrea D. Coviello(Boston University), Pio D’Adamo(IRCCS Materno Infantile Burlo Garofolo), Gail Davies(University of Edinburgh), Ulf dé Fairé(Karolinska Institutet), Eco J. C. de Geus(Vrije Universiteit Amsterdam), Ian J. Deary(University of Edinburgh), George V Z Dedoussis(Harokopio University of Athens), Panagiotis Deloukas(Wellcome Sanger Institute), Shah Ebrahim(London School of Hygiene & Tropical Medicine), Guðný Eiríksdóttir(Icelandic Heart Association), Valur Emilsson(Icelandic Heart Association), Johan G. Eriksson(Finnish Institute for Health and Welfare), Bart C.J.M. Fauser(University Medical Center Utrecht), Liana Ferreli(Institute of Genetic and Biomedical Research), Luigi Ferrucci(National Institute on Aging), Krista Fischer(University of Tartu), Aaron R. Folsom(University of Minnesota), Melissa E. Garcia(National Institutes of Health), Paolo Gasparini(IRCCS Materno Infantile Burlo Garofolo), Christian Gieger(Helmholtz Zentrum München), Nicole L. Glazer(Boston University), Diederick E. Grobbee(University Medical Center Utrecht), Per Hall(Karolinska Institutet), Toomas Haller(University of Tartu), Susan E. Hankinson(Harvard University), Merli Hass(University of Tartu), Caroline Hayward(Western General Hospital), Andrew C. Heath(Washington University in St. Louis), Albert Hofman(Erasmus MC), Erik Ingelsson(Karolinska Institutet), A. Cecile J.W. Janssens(Erasmus MC), Andrew D. Johnson(National Heart Lung and Blood Institute), David Karasik(National Heart Lung and Blood Institute), Sharon L. R. Kardia(University of Michigan), Jules J. Keyzer, Douglas P. Kiel(National Heart Lung and Blood Institute), Ivana Kolčić(University of Split), Zoltán Kutalik(University of Lausanne), Jari Lahti(University of Helsinki), Sandra Lai(Institute of Genetic and Biomedical Research), Triin Laisk(University of Tartu), Joop S.E. Laven(Erasmus MC), Debbie A. Lawlor(University of Bristol), Jianjun Liu(Genome Institute of Singapore), Lorna M. Lopez(University of Edinburgh), Yvonne V. Louwers(Erasmus MC), Patrik K. E. Magnusson(Karolinska Institutet), Mara Marongiu(Institute of Genetic and Biomedical Research), Nicholas G. Martin(QIMR Berghofer Medical Research Institute), Irena Martinović Klarić(Institute for Migration Research), Corrado Masciullo, Barbara McKnight(University of Washington), Sarah E. Medland(QIMR Berghofer Medical Research Institute), David Melzer(University of Exeter), Vincent Mooser(GlaxoSmithKline (United States)), Pau Navarro(Western General Hospital), Anne B. Newman(University of Pittsburgh), Dale R. Nyholt(QIMR Berghofer Medical Research Institute), N. Charlotte Onland‐Moret(University Medical Center Utrecht), Aarno Palotie(Wellcome Sanger Institute), Guillaume Paré(Harvard University), Alex Parker(Amgen (United States)), Nancy L. Pedersen(Karolinska Institutet), Petra H. Peeters(University Medical Center Utrecht), Giorgio Pistis, Andrew Plump(Merck & Co., Inc., Rahway, NJ, USA (United States)), Ozren Polašek(University of Split), Victor J.M. Pop(Tilburg University), Bruce M. Psaty(University of Washington), Katri Räikkönen(University of Helsinki), Emil Rehnberg(Karolinska Institutet), Jerome I. Rotter(Cedars-Sinai Medical Center), Igor Rudan(University of Split), Cinzia Sala, Andres Salumets(University of Tartu), Angelo Scuteri, Andrew B. Singleton(National Institutes of Health), Jennifer A. Smith(University of Michigan), Harold Snieder(University Medical Center Groningen), Nicole Soranzo(Wellcome Sanger Institute), Simon Stacey(deCODE Genetics (Iceland)), John M. Starr(University of Edinburgh), Maria G. Stathopoulou(Harokopio University of Athens), Kathleen Stirrups(Wellcome Sanger Institute), Ronald P. Stolk(University Medical Center Groningen), Unnur Styrkársdóttir(deCODE Genetics (Iceland)), Yan V. Sun(Emory University), Albert Tenesa(Western General Hospital), Barbara Thorand(Helmholtz Zentrum München), Daniela Toniolo, Laufey Tryggvadóttír(University of Iceland), Kim Tsui(Amgen (United States)), Sheila Ulivi(IRCCS Materno Infantile Burlo Garofolo), Rob M. van Dam(Harvard University), Yvonne T. van der Schouw(University Medical Center Utrecht), Carla H. van Gils(University Medical Center Utrecht), Peter van Nierop(GGD Brabant-Zuidoost), Jacqueline M. Vink(Vrije Universiteit Amsterdam), Peter M. Visscher(University of Edinburgh), Marlies Voorhuis(University Medical Center Utrecht), Gérard Waeber(University Hospital of Lausanne), Henri Wallaschofski(Universitätsmedizin Greifswald), H.‐Erich Wichmann(Helmholtz Zentrum München), Elisabeth Widén(University of Helsinki), Colette J.M. Wijnands-van Gent, Gonneke Willemsen(Vrije Universiteit Amsterdam), James F. Wilson(University of Edinburgh), Bruce H. R. Wolffenbuttel(University Medical Center Groningen), Alan F. Wright(Western General Hospital), Laura M. Yerges-Armstrong(University of Maryland, Baltimore), Tatijana Zemunik(University of Split), Lina Zgaga(University of Edinburgh), M. Carola Zillikens(Erasmus MC), Marek Zygmunt(Universitätsmedizin Greifswald), The LifeLines Cohort Study(University Medical Center Groningen), Alice M. Arnold(University of Washington), Dorret I Boomsma(Amsterdam Public Health), Julie E. Buring(Harvard University), Laura Crisponi(Institute of Genetic and Biomedical Research), Ellen W. Demerath(University of Minnesota), Vilmundur Guðnason(University of Iceland), Tamara B. Harris(National Institutes of Health), Frank B. Hu(Brigham and Women's Hospital), David J. Hunter(Brigham and Women's Hospital), Lenore J. Launer(National Institutes of Health), Andres Metspalu(Competence Centre on Health Technologies (Estonia)), Grant W. Montgomery(QIMR Berghofer Medical Research Institute), Ben A. Oostra(Erasmus MC), Paul M. Ridker(Harvard University), Serena Sanna(Institute of Genetic and Biomedical Research), David Schlessinger, Tim D. Spector(King's College London), Kari Stefansson(University of Iceland), Elizabeth A. Streeten(University of Maryland, Baltimore), Unnur Thorsteinsdottir(University of Iceland), Manuela Uda(Institute of Genetic and Biomedical Research), André G. Uitterlinden(Erasmus MC), Cornelia M. van Duijn(Netherlands Consortium for Healthy Ageing), Henry Völzke(Universitätsmedizin Greifswald), Anna Murray(University of Exeter), Joanne M. Murabito(National Heart Lung and Blood Institute), Jenny A. Visser(Erasmus MC), Kathryn L. Lunetta(National Heart Lung and Blood Institute)

Nature Genetics

January 22, 2012

10.1038/ng.1051

Cited by 377Open Access

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