An Antimicrobial Activity of Cytolytic T Cells Mediated by Granulysin
Steffen Stenger(Stanford University), Dennis A. Hanson(Stanford University), Rachel Teitelbaum(Stanford University), Puneet Dewan(Stanford University), Kayvan Niazi(Stanford University), Christopher J. Froelich(Stanford University), Tomas Ganz(Stanford University), Sybille Thoma-Uszynski(Stanford University), Agustı́n Melián(Stanford University), Christian Bogdan(Stanford University), Steven A. Porcelli(Stanford University), Barry R. Bloom(Stanford University), Alan M. Krensky(Stanford University), Robert L. Modlin(Stanford University)
Cited by 1,051
Abstract
Cytolytic T lymphocytes (CTLs) kill intracellular pathogens by a granule-dependent mechanism. Granulysin, a protein found in granules of CTLs, reduced the viability of a broad spectrum of pathogenic bacteria, fungi, and parasites in vitro. Granulysin directly killed extracellular Mycobacterium tuberculosis, altering the membrane integrity of the bacillus, and, in combination with perforin, decreased the viability of intracellular M. tuberculosis. The ability of CTLs to kill intracellular M. tuberculosis was dependent on the presence of granulysin in cytotoxic granules, defining a mechanism by which T cells directly contribute to immunity against intracellular pathogens.
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