<i>Pseudomonas aeruginosa</i> Pyocyanin Is Critical for Lung Infection in Mice
Gee W. Lau(Pulmonary and Critical Care Associates), Huimin Ran(Pulmonary and Critical Care Associates), Fansheng Kong(Pulmonary and Critical Care Associates), Daniel J. Hassett(University of Cincinnati Medical Center), Dmitri V. Mavrodi(Washington State University)
Cited by 360Open Access
Abstract
Pseudomonas aeruginosa secretes copious amounts of the redox-active phenazine, pyocyanin (PCN), during cystic fibrosis lung infection. PCN has been shown to interfere with a variety of cellular processes in cultured lung epithelial cells. Here, by using two respiratory tract models of infection, we demonstrate that PCN mediates tissue damage and necrosis during lung infection.
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