γ-Secretase Substrate Selectivity Can Be Modulated Directly via Interaction with a Nucleotide-binding Site
Patrick C. Fraering(Brigham and Women's Hospital), Michael S. Wolfe(Scripps Research Institute)
Cited by 99
Related Papers
Presenilins and -Secretase: Structure, Function, and Role in Alzheimer Disease
|Cold Spring Harbor Perspectives in Medicine|2011|461
Tumor Necrosis Factor-α, Interleukin-1β, and Interferon-γ Stimulate γ-Secretase-mediated Cleavage of Amyloid Precursor Protein through a JNK-dependent MAPK Pathway
|Journal of Biological Chemistry|2004|384
Nicastrin functions to sterically hinder γ-secretase–substrate interactions driven by substrate transmembrane domain
|Proceedings of the National Academy of Sciences|2015|141
The APMAP interactome reveals new modulators of APP processing and beta-amyloid production that are altered in Alzheimer’s disease
|Acta Neuropathologica Communications|2019|40
Familial Alzheimer mutations stabilize synaptotoxic γ-secretase-substrate complexes
|Cell Reports|2024|37