Direct effects of doxorubicin on skeletal muscle contribute to fatigue
Klaske van Norren(Nutricia Research (Netherlands)), Ardy van Helvoort(Danone (Netherlands)), Josep M. Argilés(Universitat de Barcelona), Sjoerd van Tuijl(Danone (Netherlands)), K Arts(Danone (Netherlands)), M. Gorselink(Danone (Netherlands)), Alessandro Laviano(Sapienza University of Rome), Diane Kegler(Danone (Netherlands)), Henk P. Haagsman(Utrecht University), Eline M. van der Beek(Danone (Netherlands))
Cited by 122Open Access
Abstract
Chemotherapy-induced fatigue is a multidimensional symptom. Oxidative stress has been proposed as a working mechanism for anthracycline-induced cardiotoxicity. In this study, doxorubicin (DOX) was tested on skeletal muscle function. Doxorubicin induced impaired ex vivo skeletal muscle relaxation followed in time by contraction impediment, which could be explained by DOX-induced changes in Ca(2+) responses of myotubes in vitro. The Ca(2+) responses in skeletal muscle, however, could not be explained by oxidative stress.
Related Papers
No related papers found
Powered by citation graph analysis