A Single Nucleotide Polymorphism in the MDM2 Promoter Attenuates the p53 Tumor Suppressor Pathway and Accelerates Tumor Formation in Humans

Gareth L. Bond; Wenwei Hu; Elisabeth E. Bond; Harlan Robins; Stuart Lutzker; Nicoleta C. Arva; Jill Bargonetti; Frank Bartel; Helge Täubert; Peter Wuerl; Kenan Onel; Linwah Yip; Shih-Jen Hwang; Louise C. Strong; Guillermina Lozano; Arnold J. Levine

doi:10.1016/j.cell.2004.11.022

A Single Nucleotide Polymorphism in the MDM2 Promoter Attenuates the p53 Tumor Suppressor Pathway and Accelerates Tumor Formation in Humans

Gareth L. Bond(Rutgers, The State University of New Jersey), Wenwei Hu(Rutgers, The State University of New Jersey), Elisabeth E. Bond(Rutgers, The State University of New Jersey), Harlan Robins(Institute for Advanced Study), Stuart Lutzker(Rutgers, The State University of New Jersey), Nicoleta C. Arva(City University of New York), Jill Bargonetti(City University of New York), Frank Bartel(Martin Luther University Halle-Wittenberg), Helge Täubert(Martin Luther University Halle-Wittenberg), Peter Wuerl(Universität Ulm), Kenan Onel(Cornell University), Linwah Yip(The University of Texas MD Anderson Cancer Center), Shih-Jen Hwang(The University of Texas MD Anderson Cancer Center), Louise C. Strong(The University of Texas MD Anderson Cancer Center), Guillermina Lozano(The University of Texas MD Anderson Cancer Center), Arnold J. Levine(Rutgers, The State University of New Jersey)

Cell

November 1, 2004

10.1016/j.cell.2004.11.022

Cited by 1,275Open Access

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