A method for normalizing histology slides for quantitative analysis
Marc Macenko(North Carolina State University), Marc Niethammer(North Carolina State University), J. S. Marron(University of North Carolina at Chapel Hill), David Borland(Renaissance Computing Institute), John T. Woosley(University of North Carolina at Chapel Hill), Xiaojun Guan(Renaissance Computing Institute), Charles Schmitt(North Carolina State University), Nancy E. Thomas(University of North Carolina at Asheville)
Cited by 1,315
Abstract
Inconsistencies in the preparation of histology slides make it difficult to perform quantitative analysis on their results. In this paper we provide two mechanisms for overcoming many of the known inconsistencies in the staining process, thereby bringing slides that were processed or stored under very different conditions into a common, normalized space to enable improved quantitative analysis.
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