Printed covalent glycan array for ligand profiling of diverse glycan binding proteins
Ola Blixt(Torrey Pines Institute For Molecular Studies), Steve Head(Torrey Pines Institute For Molecular Studies), Tony S. Mondala(Torrey Pines Institute For Molecular Studies), Christopher N. Scanlan(Torrey Pines Institute For Molecular Studies), Margaret E. Huflejt(Torrey Pines Institute For Molecular Studies), Richard Alvarez(Torrey Pines Institute For Molecular Studies), Marian C. Bryan(Torrey Pines Institute For Molecular Studies), Fabio Fazio(Torrey Pines Institute For Molecular Studies), D.A. Calarese(Torrey Pines Institute For Molecular Studies), James Stevens(Torrey Pines Institute For Molecular Studies), Nahid Razi(Torrey Pines Institute For Molecular Studies), David Stevens(Torrey Pines Institute For Molecular Studies), J.J. Skehel(Torrey Pines Institute For Molecular Studies), Irma van Die(Torrey Pines Institute For Molecular Studies), Dennis R. Burton(Torrey Pines Institute For Molecular Studies), Ian A. Wilson(Torrey Pines Institute For Molecular Studies), Richard D. Cummings(Torrey Pines Institute For Molecular Studies), Nicolai V. Bovin(Torrey Pines Institute For Molecular Studies), Chi‐Huey Wong(Torrey Pines Institute For Molecular Studies), James C. Paulson(Torrey Pines Institute For Molecular Studies)
Cited by 1,099Open Access
Abstract
Here we describe a glycan microarray constructed by using standard robotic microarray printing technology to couple amine functionalized glycans to an amino-reactive glass slide. The array comprises 200 synthetic and natural glycan sequences representing major glycan structures of glycoproteins and glycolipids. The array has remarkable utility for profiling the specificity of a diverse range of glycan binding proteins, including C-type lectins, siglecs, galectins, anticarbohydrate antibodies, lectins from plants and microbes, and intact viruses.
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