The Genome of the Western Clawed Frog <i>Xenopus tropicalis</i>
Uffe Hellsten(Joint Genome Institute), Richard M. Harland(Innovative Genomics Institute), Michael J. Gilchrist(National Institute for Medical Research), David A. Hendrix(Innovative Genomics Institute), Jerzy Jurka(Genetic Information Research Institute), Vladimir V. Kapitonov(Genetic Information Research Institute), Ivan Ovcharenko(National Institutes of Health), Nicholas H. Putnam(Rice University), Shengqiang Shu(Joint Genome Institute), Leila Taher(National Institutes of Health), Ira L. Blitz(University of California, Irvine), Bruce Blumberg(University of California, Irvine), Darwin S. Dichmann(Innovative Genomics Institute), Inna Dubchak(Joint Genome Institute), Enrique Amaya(Healing Foundation), John C. Detter(Los Alamos National Laboratory), Russell B. Fletcher(Innovative Genomics Institute), Daniela S. Gerhard(United States Department of Health and Human Services), David Goodstein(Joint Genome Institute), Tina Graves(Washington University in St. Louis), Igor V. Grigoriev(Joint Genome Institute), Jane Grimwood(Joint Genome Institute), Takeshi Kawashima(Okinawa Institute of Science and Technology Graduate University), Erika Lindquist(Joint Genome Institute), Susan Lucas(Joint Genome Institute), Paul E. Mead(St. Jude Children's Research Hospital), Therese Mitros(Innovative Genomics Institute), Hajime Ogino(Nara Institute of Science and Technology), Yuko Ohta(University of Maryland, Baltimore), Alexander V. Poliakov(Joint Genome Institute), Nicolas Pollet(Centre National de la Recherche Scientifique), Jacques Robert(University of Rochester Medical Center), Asaf Salamov(Joint Genome Institute), Amy K. Sater(University of Houston), Jeremy Schmutz(Joint Genome Institute), Astrid Terry(Joint Genome Institute), Peter D. Vize(University of Calgary), Wesley C. Warren(Washington University in St. Louis), Dan E. Wells(University of Houston), Andrea E. Wills(Innovative Genomics Institute), Richard K. Wilson(Washington University in St. Louis), Lyle B. Zimmerman, Aaron M. Zorn(Cincinnati Children's Hospital Medical Center), Robert M. Grainger(University of Virginia), Timothy C. Grammer(Innovative Genomics Institute), Mustafa K. Khokha(Yale University), Paul M. Richardson(Joint Genome Institute), Daniel S. Rokhsar(Joint Genome Institute)
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Abstract
Frog Genome The African clawed frog Xenopus tropicalis is the first amphibian to have its genome sequenced. Hellsten et al. (p. 633 , see the cover) present an analysis of a draft assembly of the genome. The genome of the frog, which is an important model system for developmental biology, encodes over 20,000 protein-coding genes, of which more than 1700 genes have identified human disease associations. Detailed comparison of the content of protein-coding genes with other tetrapods—human and chicken—reveals extensive shared synteny, occasionally spanning entire chromosomes.
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