Breast cancer susceptibility polymorphisms and endometrial cancer risk: a Collaborative Endometrial Cancer Study
Catherine S. Healey(University of Cambridge), Shahana Ahmed(Tissue Genetics (United States)), Tracy A. O’Mara(Queensland University of Technology), Kaltin Ferguson(QIMR Berghofer Medical Research Institute), Diether Lambrechts(Vlaams Instituut voor Biotechnologie), Diego A. Garcia-Dios(VIB-KU Leuven Center for Microbiology), Ignace Vergote(KU Leuven), Frédéric Amant(KU Leuven), Kimberley Howarth(University of Oxford), Maggie Gorman(Centre for Human Genetics), Shirley Hodgson(St George's Hospital), Ian Tomlinson(Centre for Human Genetics), Hannah Yang(National Institutes of Health), Jolanta Lissowska(The Maria Sklodowska-Curie National Research Institute of Oncology), Louise A. Brinton(Department of Health and Human Services), Stephen J. Chanock(Department of Health and Human Services), Montserrat García‐Closas(National Institutes of Health), Per Hall(Karolinska Institutet), Jianjun Liu(Agency for Science, Technology and Research), Mitul Shah(University of Cambridge), Paul D.P. Pharoah(University of Cambridge), Deborah J. Thompson(University of Cambridge), Timothy R. Rebbeck, Brian L. Strom(University of Pennsylvania), Alison M. Dunning(University of Cambridge), Douglas F. Easton(Department of Public Health), Amanda B. Spurdle(QIMR Berghofer Medical Research Institute)
Cited by 10Open Access
Abstract
Recent large--scale association studies, both of genome-wide and candidate gene design, have revealed several single-nucleotide polymorphisms (SNPs) which are significantly associated with risk of developing breast cancer. As both breast and endometrial cancers are considered to be hormonally driven and share multiple risk factors, we investigated whether breast cancer risk alleles are also associated with endometrial cancer risk. We genotyped nine breast cancer risk SNPs in up to 4188 endometrial cases and 11,928 controls, from between three and seven Caucasian populations. None of the tested SNPs showed significant evidence of association with risk of endometrial cancer.
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