Plasmid-Determined AmpC-Type β-Lactamases
A. Philippon(Université Paris Cité), Guillaume Arlet(Sorbonne Université), George A. Jacoby(Lahey Hospital and Medical Center)
Cited by 804Open Access
Abstract
The predominant mechanism for resistance to β-lactam antibiotics in gram-negative bacteria is the synthesis of β-lactamase. To meet this challenge, β-lactams with greater β-lactamase stability, including cephalosporins, carbapenems, and monobactams, were introduced in the 1980s. Resistance
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