The Duality of Fgl2 - Secreted Immune Checkpoint Regulator Versus Membrane-Associated Procoagulant: Therapeutic Potential and Implications
Jiemiao Hu(The University of Texas MD Anderson Cancer Center), Jun Yan(The University of Texas MD Anderson Cancer Center), Ganesh Rao(The University of Texas MD Anderson Cancer Center), Khatri Latha(The University of Texas MD Anderson Cancer Center), Willem W. Overwijk(The University of Texas MD Anderson Cancer Center), Amy B. Heimberger(The University of Texas MD Anderson Cancer Center), Shulin Li(The University of Texas MD Anderson Cancer Center)
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Abstract
Fibrinogen-like protein 2 (Fgl2), a member of the fibrinogen family, can be expressed as a membrane-associated protein with coagulation activity or in a secreted form possessing unique immune suppressive functions. The biological importance of Fgl2 is evident within viral-induced fibrin depositing inflammatory diseases and malignancies and provides a compelling rationale for Fgl2 expression to not only be considered as a disease biomarker but also as a therapeutic target. This article will provide a comprehensive review of the currently known biological properties of Fgl2 and clarifies future scientific directives.
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