Tumor Microsatellite-Instability Status as a Predictor of Benefit from Fluorouracil-Based Adjuvant Chemotherapy for Colon Cancer
Christine Ribic(Lunenfeld-Tanenbaum Research Institute), Daniel J. Sargent(Cancer Research And Biostatistics), Malcolm J. Moore(Princess Margaret Cancer Centre), Stephen N. Thibodeau, Amy J. French, Richard M. Goldberg, Stanley R. Hamilton(The University of Texas MD Anderson Cancer Center), Pierre Laurent‐Puig(Fédération Francophone de Cancérologie Digestive), Robert Gryfe(University of Toronto), Lois E. Shepherd, Dongsheng Tu, Mark Redston(Brigham and Women's Hospital), Steven Gallinger(Cancer Genetics (United States))
Cited by 2,150Open Access
Abstract
Colon cancers with high-frequency microsatellite instability have clinical and pathological features that distinguish them from microsatellite-stable tumors. We investigated the usefulness of microsatellite-instability status as a predictor of the benefit of adjuvant chemotherapy with fluorouracil in stage II and stage III colon cancer.
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