THE STRUCTURE OF DNA

John D. Watson(Cavendish Hospital), Francis Crick(Cavendish Hospital)
Cold Spring Harbor Symposia on Quantitative Biology
January 1, 1953
Cited by 1,083

Abstract

It would be superfluous at a Symposium on Vi-ruses to introduce a paper on the structure of DNA with a discussion on its importance to the problem of virus reproduction. Instead we shall not only assume that DNA is important, but in addition that it is the carrier of the genetic specificity of the virus (for argument, see Hershey, this volume) and thus must possess in some sense the capacity for exact self-duplication. In this paper we shall de-scribe a structure for DNA which suggests a mech-anism for its self-duplication and allows us to pro-pose, for the first time, a detailed hypothesis on the atomic level for the self-reproduction f genetic material. We first discuss the chemical and physical-chemi-


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