Evidence for Network Evolution in an <i>Arabidopsis</i> Interactome Map

Matija Dreze(Harvard University), Anne‐Ruxandra Carvunis(Harvard University), Benoît Charloteaux(Harvard University), Mary Galli(Salk Institute for Biological Studies), Samuel J. Pevzner(Boston University), Murat Taşan, Yong‐Yeol Ahn(Northeastern University), Padmavathi Balumuri, Albert-Ĺaszló Barabási(Northeastern University), Vanessa Bautista(Salk Institute for Biological Studies), Pascal Falter‐Braun(Harvard University), Danielle Byrdsong(Harvard University), Huaming Chen(Salk Institute for Biological Studies), Jonathan D. Chesnut, Michael E. Cusick(Harvard University), Jeffery L. Dangl, Chris de los Reyes(Salk Institute for Biological Studies), Amélie Dricot(Harvard University), Melissa Duarte(Harvard University), Joseph R. Ecker(Salk Institute for Biological Studies), Changyu Fan(Harvard University), Lantian Gai(Salk Institute for Biological Studies), Fana Gebreab(Harvard University), Gourab Ghoshal(Northeastern University), Patrick N. Gilles, Bryan J. Gutierrez(Harvard University), Tong Hao(Harvard University), David E. Hill(Harvard University), Christopher J. Kim(Salk Institute for Biological Studies), Rosa Cheuk Kim(Salk Institute for Biological Studies), Claire Lurin(Centre National de la Recherche Scientifique), Andrew MacWilliams(Harvard University), Uday Matrubutham, Tijana Milenković(University of Notre Dame), Jyotika Mirchandani, Dario Monachello(Centre National de la Recherche Scientifique), Jonathan D. Moore(University of Warwick), M. Shahid Mukhtar, Eric Olivares, Suswapna Patnaik, Matthew M. Poulin(Harvard University), Nataša Pržulj, Rosa Quan(Salk Institute for Biological Studies), Sabrina Rabello(Northeastern University), Gopalakrishna Ramaswamy, Patrick Reichert(Harvard University), Edward A. Rietman(Harvard University), Thomas Rolland(Harvard University), Viviana Romero(Harvard University), Frederick P. Roth(Harvard University), Balaji Santhanam(Harvard University), Robert J. Schmitz(Salk Institute for Biological Studies), Paul Shinn(Salk Institute for Biological Studies), William Spooner(Cold Spring Harbor Laboratory), Joshua C. Stein(Cold Spring Harbor Laboratory), Geetha M. Swamilingiah, Stanley Tam(Harvard University), Jean Vandenhaute, Marc Vidal(Harvard University), Selma Waaijers(Harvard University), Doreen Ware(Cold Spring Harbor Laboratory), Evan M. Weiner(Harvard University), Stacy Wu(Salk Institute for Biological Studies), Junshi Yazaki(Salk Institute for Biological Studies)
Science
July 28, 2011
10.1126/science.1203877
Cited by 915Open Access
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Abstract

Plants have unique features that evolved in response to their environments and ecosystems. A full account of the complex cellular networks that underlie plant-specific functions is still missing. We describe a proteome-wide binary protein-protein interaction map for the interactome network of the plant Arabidopsis thaliana containing about 6200 highly reliable interactions between about 2700 proteins. A global organization of plant biological processes emerges from community analyses of the resulting network, together with large numbers of novel hypothetical functional links between proteins and pathways. We observe a dynamic rewiring of interactions following gene duplication events, providing evidence for a model of evolution acting upon interactome networks. This and future plant interactome maps should facilitate systems approaches to better understand plant biology and improve crops.

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