Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

Robert A. Scott; Vasiliki Lagou; Ryan Welch; Eleanor Wheeler; May E. Montasser; Jian’an Luan; Reedik Mägi; Rona J. Strawbridge; Emil Rehnberg; Stefan Gustafsson; Stavroula Kanoni; Laura J. Rasmussen‐Torvik; Loïc Yengo; Cécile Lecœur; Dmitry Shungin; Serena Sanna; Carlo Sidore; P. Johnson; J. Wouter Jukema; Toby Johnson; Anubha Mahajan; Niek Verweij; Guðmar Þorleifsson; Jouke‐Jan Hottenga; Sonia Shah; Albert V. Smith; Bengt Sennblad; Christian Gieger; Perttu Salo; Markus Perola; Nicholas J. Timpson; David M. Evans; Beaté St Pourcain; Ying Wu; Jeanette S. Andrews; Jennie Hui; Lawrence F. Bielak; Wei Zhao; Momoko Horikoshi; Pau Navarro; Aaron Isaacs; Jeffrey R. O’Connell; Kathleen Stirrups; Véronique Vitart; Caroline Hayward; Tõnu Esko; Evelin Mihailov; Ross M. Fraser; Tove Fall; Benjamin F. Voight; Soumya Raychaudhuri; Han Chen; Cecilia M. Lindgren; Andrew P. Morris; Nigel W. Rayner; Neil Robertson; Denis Rybin; Ching‐Ti Liu; J. Beckmann; Sara M. Willems; Peter S. Chines; Anne Jackson; Hyun Min Kang; Heather M. Stringham; Kijoung Song; Toshiko Tanaka; John F. Peden; Anuj Goel; Andrew A. Hicks; Ping An; Martina Müller‐Nurasyid; Anders Franco‐Cereceda; Lasse Folkersen; Letizia Marullo; Hanneke Jansen; Albertine J. Oldehinkel; Marcel Bruinenberg; James S. Pankow; Kari E. North; Nita G. Forouhi; Ruth J. F. Loos; Sarah Edkins; Tibor V. Varga; Göran Hallmans; Heikki Oksa; Antonella Mulas; Ramaiah Nagaraja; Stella Trompet; Ian Ford; Stephan J. L. Bakker; Augustine Kong; Meena Kumari; Bruna Gigante; Christian Herder; Patricia B. Munroe; Mark J. Caulfield; Jula Antti; Massimo Mangino; Kerrin S. Small; Iva Miljkovic; Ching‐Ti Liu; Mustafa Atalay; Wieland Kieß; Alan L James; Fernando Rivadeneira; André G. Uitterlinden; Colin N A Palmer; Alex S. F. Doney; Gonneke Willemsen; Johannes H. Smit; Susan Campbell; Ozren Polašek; Lori L. Bonnycastle; Serge Herçberg; Maria Dimitriou; Jennifer L. Bolton; Gerard R Fowkes; Péter Kovács; Jaana Lindström; Tatijana Zemunik; Stefania Bandinelli; Sarah H. Wild; Hanneke Basart; Wolfgang Rathmann; Harald Grallert; Winfried Maerz; Marcus E. Kleber; Bernhard O. Boehm; Annette Peters; Peter P. Pramstaller; Michael A. Province; Ingrid B. Borecki; N D Hastie; Igor Rudan; Harry Campbell; Hugh Watkins; Martin Farrall; Michael Stümvoll; Luigi Ferrucci; Dawn Waterworth; Richard N. Bergman; Francis S. Collins; Jaakko Tuomilehto; Richard M. Watanabe; Eco J. C. de Geus; Brenda W.J.H. Penninx; Albert Hofman; Ben A. Oostra; Bruce M. Psaty; Péter Vollenweider; James F. Wilson; Alan F Wright; G. Kees Hovingh; Andres Metspalu; Matti Uusitupa; Patrik K. E. Magnusson; Kirsten Ohm Kyvik; Jaakko Kaprio; Jackie F. Price; George Dedoussis; Panos Deloukas; Pierre Meneton; Lars Lind; Michael Boehnke; Alan R. Shuldiner; Cornelia M. van Duijn; Andrew D Morris; Anke Toenjes; Patricia A. Peyser; John Beilby; Antje Körner; Johanna Kuusisto; Markku Laakso; Stefan R. Bornstein; Peter E. H. Schwarz; Timo A. Lakka; Rainer Rauramaa; Linda S. Adair; George Davey Smith; Tim D Spector; Thomas Illig; Ulf dé Fairé; Anders Hamsten; Vilmundur Guðnason; Mika Kivimäki; Aroon D. Hingorani; Sirkka Keinänen‐Kiukaanniemi; Timo Saaristo; Dorret I. Boomsma; Kāri Stefánsson; Pim van der Harst; Josée Dupuis; Nancy L. Pedersen; Naveed Sattar; Tamara B. Harris; Francesco Cucca; Samuli Ripatti; Veikko Salomaa; Karen L Mohlke; Beverley Balkau; Philippe Froguel; Anneli Pouta; Marjo‐Riitta Järvelin; Nicholas J. Wareham; Nabila Bouatia‐Naji; Mark I. McCarthy; Paul W. Franks; James B. Meigs; Tanya M. Teslovich; José C. Florez; Claudia Langenberg; Erik Ingelsson; Inga Prokopenko; Inês Barroso

doi:10.1038/ng.2385

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways

Robert A. Scott(Addenbrooke's Hospital), Vasiliki Lagou(Centre for Human Genetics), Ryan Welch(University of Michigan), Eleanor Wheeler(Wellcome Sanger Institute), May E. Montasser(University of Maryland, Baltimore), Jian’an Luan(Addenbrooke's Hospital), Reedik Mägi(Centre for Human Genetics), Rona J. Strawbridge(Karolinska Institutet), Emil Rehnberg(Karolinska Institutet), Stefan Gustafsson(Karolinska Institutet), Stavroula Kanoni(Wellcome Sanger Institute), Laura J. Rasmussen‐Torvik(Northwestern University), Loïc Yengo(Université Lille Nord de France), Cécile Lecœur(Université Lille Nord de France), Dmitry Shungin(Lund University), Serena Sanna(Institute of Genetic and Biomedical Research), Carlo Sidore(University of Michigan), P. Johnson(University of Glasgow), J. Wouter Jukema(Netherlands Heart Institute), Toby Johnson(Queen Mary University of London), Anubha Mahajan(Centre for Human Genetics), Niek Verweij(University Medical Center Groningen), Guðmar Þorleifsson(deCODE Genetics (Iceland)), Jouke‐Jan Hottenga(Amsterdam Public Health), Sonia Shah(University College London), Albert V. Smith(Icelandic Heart Association), Bengt Sennblad(Karolinska Institutet), Christian Gieger(Helmholtz Zentrum München), Perttu Salo(Finnish Institute for Health and Welfare), Markus Perola(University of Tartu), Nicholas J. Timpson(University of Bristol), David M. Evans(University of Bristol), Beaté St Pourcain(University of Bristol), Ying Wu(University of North Carolina at Chapel Hill), Jeanette S. Andrews(Wake Forest University), Jennie Hui(Sir Charles Gairdner Hospital), Lawrence F. Bielak(University of Michigan), Wei Zhao(University of Michigan), Momoko Horikoshi(University of Oxford), Pau Navarro(Western General Hospital), Aaron Isaacs(Centre for Medical Systems Biology), Jeffrey R. O’Connell(University of Maryland, Baltimore), Kathleen Stirrups(Wellcome Sanger Institute), Véronique Vitart(Western General Hospital), Caroline Hayward(Western General Hospital), Tõnu Esko(University of Tartu), Evelin Mihailov(University of Tartu), Ross M. Fraser(University of Edinburgh), Tove Fall(Karolinska Institutet), Benjamin F. Voight(Broad Institute), Soumya Raychaudhuri(Brigham and Women's Hospital), Han Chen(Boston University), Cecilia M. Lindgren(Centre for Human Genetics), Andrew P. Morris(Centre for Human Genetics), Nigel W. Rayner(University of Oxford), Neil Robertson(University of Oxford), Denis Rybin(Boston University), Ching‐Ti Liu(Boston University), J. Beckmann(University of Lausanne), Sara M. Willems(Erasmus MC), Peter S. Chines(National Institutes of Health), Anne Jackson(University of Michigan), Hyun Min Kang(University of Michigan), Heather M. Stringham(University of Michigan), Kijoung Song(GlaxoSmithKline (United States)), Toshiko Tanaka(National Institute on Aging), John F. Peden(Centre for Human Genetics), Anuj Goel(Centre for Human Genetics), Andrew A. Hicks(Eurac Research), Ping An(Washington University in St. Louis), Martina Müller‐Nurasyid(Helmholtz Zentrum München), Anders Franco‐Cereceda(Karolinska Institutet), Lasse Folkersen(Karolinska University Hospital), Letizia Marullo(Centre for Human Genetics), Hanneke Jansen(University Medical Center Groningen), Albertine J. Oldehinkel(University Medical Center Groningen), Marcel Bruinenberg(University Medical Center Groningen), James S. Pankow(University of Minnesota), Kari E. North(University of North Carolina at Chapel Hill), Nita G. Forouhi(Addenbrooke's Hospital), Ruth J. F. Loos(Addenbrooke's Hospital), Sarah Edkins(Wellcome Sanger Institute), Tibor V. Varga(Lund University), Göran Hallmans(Umeå University), Heikki Oksa(Pirkanmaa Hospital District), Antonella Mulas(Institute of Genetic and Biomedical Research), Ramaiah Nagaraja(National Institute on Aging), Stella Trompet(Netherlands Heart Institute), Ian Ford(University of Glasgow), Stephan J. L. Bakker(University Medical Center Groningen), Augustine Kong(deCODE Genetics (Iceland)), Meena Kumari(University College London), Bruna Gigante(Karolinska Institutet), Christian Herder(Deutsches Diabetes-Zentrum e.V.), Patricia B. Munroe(Queen Mary University of London), Mark J. Caulfield(Queen Mary University of London), Jula Antti(Finnish Institute for Health and Welfare), Massimo Mangino(King's College London), Kerrin S. Small(King's College London), Iva Miljkovic(University of Pittsburgh), Ching‐Ti Liu(Wake Forest University), Mustafa Atalay(University of Eastern Finland), Wieland Kieß(IFB Adiposity Diseases), Alan L James(Sir Charles Gairdner Hospital), Fernando Rivadeneira(Centre for Medical Systems Biology), André G. Uitterlinden(Centre for Medical Systems Biology), Colin N A Palmer(University of Dundee), Alex S. F. Doney(University of Dundee), Gonneke Willemsen(Amsterdam Public Health), Johannes H. Smit(Amsterdam UMC Location Vrije Universiteit Amsterdam), Susan Campbell(Western General Hospital), Ozren Polašek(University of Split), Lori L. Bonnycastle(National Institutes of Health), Serge Herçberg(Inserm), Maria Dimitriou(Harokopio University of Athens), Jennifer L. Bolton(University of Edinburgh), Gerard R Fowkes(University of Edinburgh), Péter Kovács(Leipzig University), Jaana Lindström(Finnish Institute for Health and Welfare), Tatijana Zemunik(University of Split), Stefania Bandinelli(Azienda Sanitaria di Firenze), Sarah H. Wild(University of Edinburgh), Hanneke Basart(Amsterdam UMC Location University of Amsterdam), Wolfgang Rathmann(Deutsches Diabetes-Zentrum e.V.), Harald Grallert(Helmholtz Zentrum München), Winfried Maerz(Synlab (Germany)), Marcus E. Kleber(University of Mannheim), Bernhard O. Boehm(University Hospital Ulm), Annette Peters(Helmholtz Zentrum München), Peter P. Pramstaller(University of Oxford), Michael A. Province(Washington University in St. Louis), Ingrid B. Borecki(Washington University in St. Louis), N D Hastie(Western General Hospital), Igor Rudan(University of Edinburgh), Harry Campbell(University of Edinburgh), Hugh Watkins(University of Oxford), Martin Farrall(University of Oxford), Michael Stümvoll(IFB Adiposity Diseases), Luigi Ferrucci(National Institute on Aging), Dawn Waterworth(GlaxoSmithKline (United States)), Richard N. Bergman(Cedars-Sinai Medical Center), Francis S. Collins(National Institutes of Health), Jaakko Tuomilehto(Finnish Institute for Health and Welfare), Richard M. Watanabe(University of Southern California), Eco J. C. de Geus(Amsterdam Public Health), Brenda W.J.H. Penninx(Amsterdam UMC Location Vrije Universiteit Amsterdam), Albert Hofman(Erasmus MC), Ben A. Oostra(Centre for Medical Systems Biology), Bruce M. Psaty(University of Washington), Péter Vollenweider(University of Lausanne), James F. Wilson(University of Edinburgh), Alan F Wright(Western General Hospital), G. Kees Hovingh(Amsterdam UMC Location University of Amsterdam), Andres Metspalu(University of Tartu), Matti Uusitupa(University of Eastern Finland), Patrik K. E. Magnusson(Karolinska Institutet), Kirsten Ohm Kyvik, Jaakko Kaprio(University of Helsinki), Jackie F. Price(University of Edinburgh), George Dedoussis(Harokopio University of Athens), Panos Deloukas(Wellcome Sanger Institute), Pierre Meneton(Centre de Recherche des Cordeliers), Lars Lind(Uppsala University), Michael Boehnke(University of Michigan), Alan R. Shuldiner(University of Maryland, Baltimore), Cornelia M. van Duijn(Erasmus MC), Andrew D Morris(University of Dundee), Anke Toenjes(IFB Adiposity Diseases), Patricia A. Peyser(University of Michigan), John Beilby(Pathwest Laboratory Medicine), Antje Körner(IFB Adiposity Diseases), Johanna Kuusisto(University of Eastern Finland), Markku Laakso(University of Eastern Finland), Stefan R. Bornstein(University Hospital Carl Gustav Carus), Peter E. H. Schwarz(University Hospital Carl Gustav Carus), Timo A. Lakka(University of Eastern Finland), Rainer Rauramaa(University of Eastern Finland), Linda S. Adair(University of North Carolina at Chapel Hill), George Davey Smith(University of Bristol), Tim D Spector(King's College London), Thomas Illig(Helmholtz Zentrum München), Ulf dé Fairé(Karolinska Institutet), Anders Hamsten(Karolinska University Hospital), Vilmundur Guðnason(University of Iceland), Mika Kivimäki(University College London), Aroon D. Hingorani(University College London), Sirkka Keinänen‐Kiukaanniemi(University of Oulu), Timo Saaristo(Pirkanmaa Hospital District), Dorret I. Boomsma(Amsterdam Public Health), Kāri Stefánsson(University of Iceland), Pim van der Harst(University Medical Center Groningen), Josée Dupuis(Boston University), Nancy L. Pedersen(Karolinska Institutet), Naveed Sattar(British Heart Foundation), Tamara B. Harris(National Institute on Aging), Francesco Cucca(University of Sassari), Samuli Ripatti(University of Helsinki), Veikko Salomaa(Finnish Institute for Health and Welfare), Karen L Mohlke(University of North Carolina at Chapel Hill), Beverley Balkau(Inserm), Philippe Froguel(Hammersmith Hospital), Anneli Pouta(University of Oulu), Marjo‐Riitta Järvelin(Finnish Institute for Health and Welfare), Nicholas J. Wareham(Addenbrooke's Hospital), Nabila Bouatia‐Naji(Inserm), Mark I. McCarthy(Churchill Hospital), Paul W. Franks(Harvard University), James B. Meigs(Massachusetts General Hospital), Tanya M. Teslovich(University of Michigan), José C. Florez(Harvard University), Claudia Langenberg(University College London), Erik Ingelsson(Karolinska Institutet), Inga Prokopenko(University of Oxford), Inês Barroso(Addenbrooke's Hospital)

Nature Genetics

August 12, 2012

10.1038/ng.2385

Cited by 857Open Access

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