Intransal or intragastric immunization with proteosome-Shigella lipopolysaccharide vaccines protects against lethal pneumonia in a murine model of Shigella infection
Corey P. Mallett(Walter Reed Army Institute of Research), Thomas L. Hale(Walter Reed Army Institute of Research), Robert W. Kaminski(Walter Reed Army Institute of Research), Thomas Larsen(Walter Reed Army Institute of Research), Nadav Orr(Walter Reed Army Institute of Research), Dani Cohen(Walter Reed Army Institute of Research), George H. Lowell(Walter Reed Army Institute of Research)
Cited by 80Open Access
Abstract
Mice immunized intransally or intragastrically with proteosome vaccines containing either Shigella sonnei or S. flexneri 2a lipopolysaccharide were protected against lethal pneumonia caused by homologous organisms in an experimental murine intranasal challenge model of Shigella infection. Histopathological analysis demonstrated that immunization also protected against the progressive lesions resulting from invasion of the pulmonary mucosa by S. sonnei. These data show that mucosal proteosome-lipopolysaccharide vaccines can protect against lethal bacterial pneumonia and indicate that such vaccines are promising candidates for protection against intestinal shigellosis.
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