Statics and Dynamics of Single DNA Molecules Confined in Nanochannels
Walter Reisner(Princeton University), Keith Morton(Princeton University), Robert Riehn(Princeton University), Yan Mei Wang(Princeton University), Zhaoning Yu(Princeton University), Michael Rosen(Stanford University), James C. Sturm(Princeton University), Stephen Y. Chou(Princeton University), Erwin Frey(Ludwig-Maximilians-Universität München), Robert H. Austin(Princeton University)
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Abstract
The successful design of nanofluidic devices for the manipulation of biopolymers requires an understanding of how the predictions of soft condensed matter physics scale with device dimensions. Here we present measurements of DNA extended in nanochannels and show that below a critical width roughly twice the persistence length there is a crossover in the polymer physics.
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