A uniform system for microRNA annotation
Victor Ambros(Dartmouth College), Bonnie Bartel(Rice University), David P. Bartel(Whitehead Institute for Biomedical Research), Christopher B. Burge(Massachusetts Institute of Technology), James C. Carrington(Oregon State University), Xuemei Chen(Rutgers, The State University of New Jersey), Gideon Dreyfuss(Howard Hughes Medical Institute), Sean R. Eddy(Howard Hughes Medical Institute), Sam Griffiths‐Jones(Wellcome Sanger Institute), Mhairi Marshall(Wellcome Sanger Institute), Marjori Matzke(Austrian Academy of Sciences), Gary Ruvkun(Harvard University), Thomas Tuschl(Max Planck Society)
Cited by 1,901Open Access
Abstract
MicroRNAs (miRNAs) are small noncoding RNA gene products about 22 nt long that are processed by Dicer from precursors with a characteristic hairpin secondary structure. Guidelines are presented for the identification and annotation of new miRNAs from diverse organisms, particularly so that miRNAs can be reliably distinguished from other RNAs such as small interfering RNAs. We describe specific criteria for the experimental verification of miRNAs, and conventions for naming miRNAs and miRNA genes. Finally, an online clearinghouse for miRNA gene name assignments is provided by the Rfam database of RNA families.
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