Human Protein Reference Database--2009 update

Thottethodi Subrahmanya Keshava Prasad(Institute of Bioinformatics), Renu Goel(Johns Hopkins University), K. Kandasamy(Johns Hopkins University), Shivakumar Keerthikumar(Johns Hopkins University), Santosh Kumar(Johns Hopkins University), Suresh Mathivanan(Johns Hopkins University), Deepthi Telikicherla(Johns Hopkins University), Rajesh Raju(Johns Hopkins University), Rajamohamed Beema Shafreen(Johns Hopkins University), Anilrudh A. Venugopal(Johns Hopkins University), Lavanya Balakrishnan(Johns Hopkins University), Arivusudar Marimuthu(Johns Hopkins University), Sangeeta Ray Banerjee(Johns Hopkins University), D. S. Somanathan(Johns Hopkins University), Aimy Sebastian(Johns Hopkins University), S Prathibha Rani(Johns Hopkins University), Somak Ray(Johns Hopkins University), C. J. Harrys Kishore(Johns Hopkins University), S.M. Kanth(Johns Hopkins University), Mukhtar Ahmed(Johns Hopkins University), Manoj Kumar Kashyap(Johns Hopkins University), Riaz Mohmood(Johns Hopkins University), YL Ramachandra(Johns Hopkins University), V. Krishna(Johns Hopkins University), B. A. Rahiman(Johns Hopkins University), Sachin Mohan(Johns Hopkins University), Prathibha Ranganathan(Johns Hopkins University), S. Ramabadran(Johns Hopkins University), Raghothama Chaerkady(Johns Hopkins University), Akhilesh Pandey(Johns Hopkins University)
Nucleic Acids Research
November 6, 2008
10.1093/nar/gkn892
Cited by 3,304Open Access
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Abstract

Human Protein Reference Database (HPRD--http://www.hprd.org/), initially described in 2003, is a database of curated proteomic information pertaining to human proteins. We have recently added a number of new features in HPRD. These include PhosphoMotif Finder, which allows users to find the presence of over 320 experimentally verified phosphorylation motifs in proteins of interest. Another new feature is a protein distributed annotation system--Human Proteinpedia (http://www.humanproteinpedia.org/)--through which laboratories can submit their data, which is mapped onto protein entries in HPRD. Over 75 laboratories involved in proteomics research have already participated in this effort by submitting data for over 15,000 human proteins. The submitted data includes mass spectrometry and protein microarray-derived data, among other data types. Finally, HPRD is also linked to a compendium of human signaling pathways developed by our group, NetPath (http://www.netpath.org/), which currently contains annotations for several cancer and immune signaling pathways. Since the last update, more than 5500 new protein sequences have been added, making HPRD a comprehensive resource for studying the human proteome.

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