Pd‐Catalyzed Amination of Nucleoside Arylsulfonates to yield <i>N</i>⁶‐Aryl‐2,6‐Diaminopurine Nucleosides

Abstract

Substituents on both the nucleoside arylsulfonate as well as the aryl amine component have a significant impact on their coupling to form 2,6-diaminopurine-2′-deoxyribonucleosides (see scheme). A systematic study of ligands for the Pd catalysts in amination and CC cross-coupling reactions gives insight into the structural elements that lead to effective catalysis.