Cloning and Characterization of the Biosynthetic Gene Cluster for Tomaymycin, an SJG-136 Monomeric Analog
Wei Li(University of Maryland, College Park), Shen‐Chieh Chou(University of Maryland, College Park), Ankush Khullar(University of Maryland, College Park), Barbara Gerratana(University of Maryland, College Park)
Cited by 95Open Access
Abstract
Tomaymycin produced by Streptomyces achromogenes is a naturally produced pyrrolobenzodiazepine (PBD). The biosynthetic gene cluster for tomaymycin was identified and sequenced. The gene cluster analysis reveals a novel biosynthetic pathway for the anthranilate moiety of PBDs. Gene replacement and chemical complementation studies were used to confirm the proposed biosynthetic pathway.
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