Platensimycin is a selective FabF inhibitor with potent antibiotic properties

Jun Wang; S.M. Soisson; Katherine Young; Wesley L. Shoop; Srinivas Kodali; Andrew Galgoci; Ronald E. Painter; Gopalakrishnan Parthasarathy; Yui S. Tang; Richard Cummings; Sookhee Ha; Karen Dorso; Mary Motyl; Hiranthi Jayasuriya; John G. Ondeyka; Kithsiri Herath; Chaowei Zhang; Lorraine D. Hernandez; John Allocco; Ángela Basilio; José R. Tormo; Olga Genilloud; Francisca Vicente; Fernando Peláez; Lawrence F. Colwell; Sang Ho Lee; Bruce Michael; T. Felcetto; Charles Gill; Lynn L. Silver; Jeffery D. Hermes; Ken Bartizal; J. Barrett; Dennis M. Schmatz; Joseph W. Becker; Doris Cully; Sheo B. Singh

doi:10.1038/nature04784

Platensimycin is a selective FabF inhibitor with potent antibiotic properties

Jun Wang(Merck & Co., Inc., Rahway, NJ, USA (United States)), S.M. Soisson(Merck & Co., Inc., Rahway, NJ, USA (United States)), Katherine Young(Merck & Co., Inc., Rahway, NJ, USA (United States)), Wesley L. Shoop(DuPont (United States)), Srinivas Kodali(Merck & Co., Inc., Rahway, NJ, USA (United States)), Andrew Galgoci(Merck & Co., Inc., Rahway, NJ, USA (United States)), Ronald E. Painter(Merck & Co., Inc., Rahway, NJ, USA (United States)), Gopalakrishnan Parthasarathy(Merck & Co., Inc., Rahway, NJ, USA (United States)), Yui S. Tang(Merck & Co., Inc., Rahway, NJ, USA (United States)), Richard Cummings(Merck & Co., Inc., Rahway, NJ, USA (United States)), Sookhee Ha(Merck & Co., Inc., Rahway, NJ, USA (United States)), Karen Dorso(Merck & Co., Inc., Rahway, NJ, USA (United States)), Mary Motyl(Merck & Co., Inc., Rahway, NJ, USA (United States)), Hiranthi Jayasuriya(Merck & Co., Inc., Rahway, NJ, USA (United States)), John G. Ondeyka(Merck & Co., Inc., Rahway, NJ, USA (United States)), Kithsiri Herath(Merck & Co., Inc., Rahway, NJ, USA (United States)), Chaowei Zhang(Merck & Co., Inc., Rahway, NJ, USA (United States)), Lorraine D. Hernandez(Merck & Co., Inc., Rahway, NJ, USA (United States)), John Allocco(Merck & Co., Inc., Rahway, NJ, USA (United States)), Ángela Basilio(Merck & Co., Inc., Rahway, NJ, USA (United States)), José R. Tormo(Merck & Co., Inc., Rahway, NJ, USA (United States)), Olga Genilloud(Merck & Co., Inc., Rahway, NJ, USA (United States)), Francisca Vicente(Merck & Co., Inc., Rahway, NJ, USA (United States)), Fernando Peláez(Merck & Co., Inc., Rahway, NJ, USA (United States)), Lawrence F. Colwell(Merck & Co., Inc., Rahway, NJ, USA (United States)), Sang Ho Lee(Merck & Co., Inc., Rahway, NJ, USA (United States)), Bruce Michael(Merck & Co., Inc., Rahway, NJ, USA (United States)), T. Felcetto(Merck & Co., Inc., Rahway, NJ, USA (United States)), Charles Gill(Merck & Co., Inc., Rahway, NJ, USA (United States)), Lynn L. Silver(Merck & Co., Inc., Rahway, NJ, USA (United States)), Jeffery D. Hermes(Merck & Co., Inc., Rahway, NJ, USA (United States)), Ken Bartizal(Merck & Co., Inc., Rahway, NJ, USA (United States)), J. Barrett(Merck & Co., Inc., Rahway, NJ, USA (United States)), Dennis M. Schmatz(Merck & Co., Inc., Rahway, NJ, USA (United States)), Joseph W. Becker(Merck & Co., Inc., Rahway, NJ, USA (United States)), Doris Cully(Merck & Co., Inc., Rahway, NJ, USA (United States)), Sheo B. Singh(Merck & Co., Inc., Rahway, NJ, USA (United States))

Nature

May 1, 2006

10.1038/nature04784

Cited by 813

Abstract

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